We investigate the error versus reject tradeo for classi ers. Our analysis is motivated by the remarkable similarity in error-reject tradeo curves for widely di ering algorithms classifying handwritten characters. We present the data in a new scaled version that makes this universal character particularly evident. Based on Chow's theory of the error-reject tradeo and its underlying Bayesian ana...

The TIM (T cell immunoglobulin mucin) proteins have emerged as key regulators of allergic and autoimmune diseases due to their influence on T helper (Th)-1 and Th-2 responses. On page 955, Chen and colleagues show that one member of this family, TIM-2, multitasks as a receptor for H-ferritin, a component of the iron storage protein ferritin. Ferritin was not what the group expected to find when...

A protein known for its role in dismantling faulty SNARE complexes can also help to maintain complexes that have formed properly during membrane fusion.