نتایج جستجو برای: SH-SY 5Y cells

تعداد نتایج: 1393815  

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2011
Swati S More Melissa Itsara Xiaodong Yang Ethan G Geier Michelle K Tadano Youngho Seo Henry F Vanbrocklin William A Weiss Sabine Mueller Daphne A Haas-Kogan Steven G Dubois Katherine K Matthay Kathleen M Giacomini

PURPOSE Histone deacetylase (HDAC) inhibition causes transcriptional activation or repression of several genes that in turn can influence the biodistribution of other chemotherapeutic agents. Here, we hypothesize that the combination of vorinostat, a HDAC inhibitor, with (131)I-meta-iodobenzylguanidine (MIBG) would lead to preferential accumulation of the latter in neuroblastoma (NB) tumors via...

2011
Swati S. More Melissa Itsara Xiaodong Yang Ethan G. Geier Michelle K. Tadano Youngho Seo Henry F. VanBrocklin William A. Weiss Sabine Mueller Daphne A. Haas-Kogan Steven G. DuBois Katherine K. Matthay Kathleen M. Giacomini

Purpose: Histone deacetylase (HDAC) inhibition causes transcriptional activation or repression of several genes that in turn can influence the biodistribution of other chemotherapeutic agents. Here, we hypothesize that the combination of vorinostat, a HDAC inhibitor, with I-meta-iodobenzylguanidine (MIBG) would lead to preferential accumulation of the latter in neuroblastoma (NB) tumors via inc...

Journal: :Journal of the National Cancer Institute 1997
P E Lovat H Irving M Annicchiarico-Petruzzelli F Bernassola A J Malcolm A D Pearson G Melino C P Redfern

BACKGROUND The overall survival rate for patients with neuroblastoma has improved over the past two decades, but long-term survival for the subgroup of patients with high-risk disease remains low. In recent years, there has been interest in the potential clinical use of drugs able to induce differentiation of neuroblastoma cells. Since 9-cis-retinoic acid induces better and more sustained diffe...

Journal: :Neurobiology of disease 1997
L Dupont-Wallois C Soulié N Sergeant N Wavrant-de Wrieze M C Chartier-Harlin A Delacourte M L Caillet-Boudin

Apolipoprotein E (apoE) is associated with the two hallmarks of Alzheimer's disease: A beta deposits and neurofibrillary tangles. ApoE synthesis was detected in astrocytes by in situ hybridization but was not detected in neurons. Nevertheless, different studies on apoE immunoreactivity reported the presence of apoE in neurons of Alzheimer, control, and necrosis pontisubicular brains. In this st...

Journal: :Applied sciences 2022

Background: This study investigated the effect of a mixture Gastrodiae elata and Glycyrrhizae uralensis (GGW) on β-amyloid-induced neuronal damage in vitro. Methods: For finding appropriate GGW ratio, we performed MTT assays using ratios 5:5, 6:4, 7:3, 8:2 9:1 SK-N-SH cell SH-SY-5Y cell. Treatment with β-amyloid (10 μM) caused death overexpression acetylcholinesterase (ACHE) cells. treatment in...

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