conclusions the use of sof + pr regimen or ldv/sof can significantly reduce the incidence of complications associated with the disease. for example, short and long-term outcomes are better than the current drug regimens for hcv genotype 1 patients in all stages of the disease. objectives this study is aimed to assess the cost-effectiveness of the three drug regimens of pegylated interferon and ...

Serum opacity factor (SOF) is a cell surface virulence factor made by the human pathogen Streptococcus pyogenes. We found that S. pyogenes strains with naturally occurring truncation mutations in the sof gene have markedly enhanced beta-hemolysis. Moreover, deletion of the sof gene in a SOF-positive parental strain resulted in significantly increased beta-hemolysis. Together, these observations...

S282T in NS5B is the primary amino acid substitution associated with resistance to sofosbuvir (SOF) but has rarely been detected in patients treated with a SOF-based regimen. Here, the emergence and fitness of the S282T substitution in virologic failure patients administered SOF-based regimens across the SOF and ledipasvir (LDV)/SOF phase 2 and 3 programs was evaluated. Plasma samples collected...

Background/Aims The approval of sofosbuvir (SOF), a direct-acting antiviral, has revolutionized the treatment of chronic hepatitis C virus (HCV). Methods We assessed the sustained virological response (SVR) of SOF-based regimens in a real-world single-center setting for the treatment of chronic HCV genotype 1 (G1) patients. This was a retrospective review of chronic HCV G1 adult patients trea...

BACKGROUND With the appearance of oral direct-acting antivirals (DAAs), the field of hepatitis C virus (HCV) treatment has been dramatically changed. This evolution makes possible for all oral treatments to be available for the treatment of HCV-infected patients. The aims of this review were to report the efficacy and safety of sofosbuvir (SOF)-based regimens for the treatment of patients with ...

Fig. 1. (a) Estimates of SVR12 achievement, medians with 95% CrIs, calculated by the Bayesian model. The numerical values of these estimates are as follows: SOF/LED-12 weeks, 93.17 (95% CrI: 98.35–99.76); SOF/LED-8 weeks, 77.84 (95% CrI: 93.64–98.71); SOF/DAC, 87.62 (95% CrI: 99.56–100); ARIOD, 83.42 (95% CrI: 93.88–97.93); and ARIODR, 93.15 (95% CrI: 97.27–99.12). (b) Histograms of rankings es...

In this talk, we investigate the question of whether and how 'second occurrence focus' (SOF) is realized phonetically in German. We point out that preceding studies overlooked various phonetic effects that are independently motivated in the SOF sentences, hence failing to have a complete explanation of the SOF phenomenon. We present convincing evidence for the phonetic marking of SOF, and propo...

AIM To assess the real-world effectiveness and cost of simeprevir (SMV), and/or sofosbuvir (SOF)-based therapy for chronic hepatitis C virus (HCV) infection. METHODS The real-world performance of patients treated with SMV/SOF ± ribavirin (RBV), SOF/RBV, and SOF/RBV with pegylated-interferon (PEG) were analyzed in a consecutive series of 508 patients with chronic HCV infection treated at a sin...

In metazoans, there is a remarkable diversity of photosensitive structures; their shapes, physiology, optical properties, and development are different. To approach the evolution of photosensitive structures and visual function, cephalopods are particularly interesting organisms due to their most highly centralized nervous system and their camerular eyes which constitute a convergence with thos...

BACKGROUND Real-time measurement of thermal neutrons in the tumor region is essential for proper evaluation of the absorbed dose in boron neutron capture therapy (BNCT) treatment. The gold wire activation method has been routinely used to measure the neutron flux distribution in BNCT irradiation, but a real-time measurement using gold wire is not possible. To overcome this issue, the scintillat...