Drug resistance poses a significant threat to ongoing malaria control efforts. Coupled with lack of a malaria vaccine, there is an urgent need for the development of new antimalarials with novel mechanisms of action and low susceptibility to parasite drug resistance. Protein Kinase A (PKA) has been implicated as a critical regulator of pathogenesis in malaria. Therefore, we sought to investigat...

AIM Stomach adenocarcinoma (STAD) is a common malignancy worldwide. This study aimed to identify the aberrantly expressed long non-coding RNAs (lncRNAs) in STAD. RESULTS Total of 74 DElncRNAs and 449 DEmRNAs were identified in STAD compared with paired non-tumor tissues. The DElncRNA/DEmRNA co-expression network was constructed, which covered 519 nodes and 2993 edges. The qRT-PCR validation r...

The purpose of our study is to identify epigenetic markers that are differently expressed in the stomach adenocarcinoma (STAD) condition. Based on data from The Cancer Genome Atlas (TCGA), we were able to detect an age-related difference in methylation patterns and changes in gene and miRNA expression levels in young (n = 14) and old (n = 70) STAD subjects. Our analysis identified 323 upregulat...

Stomach adenocarcinoma (STAD) is one of the leading causes of cancer morbidity and mortality worldwide. The present study aimed to identify the microRNAs associated with STAD survival time. The clinical information and microarray miRNA and mRNA expression profiles of STAD patients were downloaded from The Cancer Genome Atlas. Differential expression (DE) analysis was performed to identify DEmiR...

Scholars in student learning have shown a growing interest in using Student Teams Achievement Divisions (STAD) as a cooperative learning technique in classroom teaching. This study explores the effects of STAD on student achievement, attitude and motivation in economics education. Three research instruments, a Test of Economic Literacy (TEL); a Motivation Scale and an Economics Modular Test wer...

PURPOSE Randomized trials have corroborated the clinical benefit of adding androgen deprivation (AD) to radiotherapy (RT) in the treatment of high-risk prostate cancer. Another competing strategy is to escalate the RT dose using three-dimensional conformal RT (3D-CRT). In this analysis, we asked whether the addition of short-term AD (STAD) (<or=6 months) to RT in the treatment of high-risk (pro...

Recent microRNA (miRNA) expression profiling studies suggest the clinical use of miRNAs as potential prognostic biomarkers in various malignancies. In this study, aiming to identify microRNAs with prognostic value for overall survival (OS) in stomach adenocarcinoma (STAD) patients, we analyzed the miRNA expression profiles and the associated clinical characteristics in 380 STAD samples from The...

BACKGROUND In Radiation Therapy Oncology Group (RTOG) trial 92-02, after men received neoadjuvant hormone cytoreduction and radiotherapy for locally advanced prostate carcinoma, they were randomized to receive either 2 years of long-term androgen-deprivation (LTAD) or no further treatment (short-term androgen-deprivation [STAD]). The specific objective of the current study was to determine whet...

Die Voorkomende Gemeenskapsgeriatriesedienste wat vir die afgeiope tien jaar in die Stad Germiston gelewer word, word kortliks uiteengesit. Hierdie dienste is beskikbaar aan alle inwoners van die Stad wie ouer as 60 jaar is en bestaan, onder andere, uit siftingskliniekdienste en voetkundige dienste. Daar word ook tuisbesoeke gedoen om kontak te hou met bejaarde kliente sowel as om met hul probl...

Gas production (GP) and starch degradation (STAD) from starchy feedstuffs were measured simultaneously by in-vitro incubation in buffered rumen fluid after 0, 4, 6, 8, 12, 16 and 24 h incubation to explore the possibility to estimate STAD via GP technique for starchy feedstuffs. The results showed the ranking in the initial degree of starch degradation and gas production. Potato starch and maiz...