SARI is associated with the risk for several cancers, and loss of SARI expression is frequently found in aggressive and metastatic cancer. Limited evidence shows that SARI is a tumor suppressor gene, but the role of SARI in non-small cell lung cancer (NSCLC) has not been previously reported. This study was to investigate the SARI expression profile in surgically resected lung cancer tissues of ...

SARI, also called as BATF2, belongs to the BATF family and has been implicated in cancer cell growth inhibition. However, the role and mechanism of SARI in tumour angiogenesis are elusive. Here we demonstrate that SARI deficiency facilitates AOM/DSS-induced colonic tumorigenesis in mice. We show that SARI is a novel inhibitor of colon tumour growth and angiogenesis in mice. Antibody array and H...

1Department of Pediatrics, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran 2Department of Medical Mycology and Parasitology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran 3Department of Medical Mycology and Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran 4Invasive Fungi Research Center, Mazandaran Univer...

BACKGROUND Understanding the burden of influenza-associated severe acute respiratory infection (SARI) is important for setting national influenza surveillance and vaccine priorities. Estimating influenza-associated SARI rates requires hospital-based surveillance data and a population-based denominator, which can be challenging to determine. OBJECTIVES We present an application of the World He...

BACKGROUND The World Health Organisation recommends outpatient influenza-like illness (ILI) and inpatient severe acute respiratory illness (SARI) surveillance. We evaluated two influenza surveillance systems in South Africa: one for ILI and another for SARI. METHODOLOGY The Viral Watch (VW) programme has collected virological influenza surveillance data voluntarily from patients with ILI sinc...

Associate Professor, Department of Internal Medicine, Diabetes Research Centre, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Associate Professor, Department of Biostatistics, Diabetes Research Centre, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran. Assistant Professor, Department of Healthcare Management, Amol Faculty of Nursing and Midwi...

BACKGROUND The 2009 H1N1 pandemic highlighted the need to routinely monitor severe influenza, which lead to the establishment of sentinel hospital-based surveillance of severe acute respiratory infections (SARI) in several countries in Europe. The objective of this study is to describe characteristics of SARI patients and to explore risk factors for a severe outcome in influenza-positive SARI p...

Zeinab Hamzehgardeshi, Mina Malary, Mahmood Moosazadeh, Soghra Khani, Mehdi Pourasghar. Assistant professor, Department of Reproductive Health and Midwifery, Mazandaran University of Medical Sciences, Sari, Iran; Assistant professor, Department of Reproductive Health and Midwifery, Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran; Assistant professor, Health Sci...

Given the rapid rate of global spread and consequently healthcare costs related to influenza, surveillance plays an important role in monitoring the emerging pandemics in China. However, the characteristics of influenza in Southeast of China haven't been fully studied. Our study use the surveillance data collected from 16 sentinel hospitals across Zhejiang Province during March 2011 through Jun...

Subtraction hybridization combined with induction of cancer cell terminal differentiation in human melanoma cells identified melanoma differentiation-associated gene-7/interleukin-24 (mda-7/IL-24) and SARI (suppressor of AP-1, induced by IFN) that display potent antitumor activity. These genes are not constitutively expressed in cancer cells and forced expression of mda-7/IL-24 (Ad.mda-7) or SA...