Palladium doped silica membranes were synthesized by the sol-gel method using two different procedures. The first palladium-doped silica membrane (M1) was synthesized with a coating of four layers of silica-palladium sol. The second membrane (M2) was synthesized with a coating of two silica layers followed by a coating of two silica-palladium layers. Scanning electron microscopy (SEM) proved th...

KEY POINTS Kainate receptor heteromerization and auxiliary subunits, Neto1 and Neto2, attenuate polyamine ion-channel block by facilitating blocker permeation. Relief of polyamine block in GluK2/GluK5 heteromers results from a key proline residue that produces architectural changes in the channel pore α-helical region. Auxiliary subunits exert an additive effect to heteromerization, and thus re...

Rationale: Canonical transient receptor potential 4 (TRPC4) contributes to the molecular composition of a channel encoding for a calcium selective store-operated current, ISOC, whereas Orai1 critically comprises a channel encoding for the highly selective calcium release activated calcium current, ICRAC. However, Orai1 may interact with TRPC proteins and influence their activation and permeatio...

RATIONALE Canonical transient receptor potential 4 (TRPC4) contributes to the molecular composition of a channel encoding for a calcium selective store-operated current, I(SOC), whereas Orai1 critically comprises a channel encoding for the highly selective calcium release activated calcium current, I(CRAC). However, Orai1 may interact with TRPC proteins and influence their activation and permea...

In article number 2100782, Shin-Hyun Kim and co-workers design thermo-responsive microcapsules with ultra-thin hydrogel membranes. The show molecular-size-selective transmembrane permeation due to the consistent mesh size of membrane. More importantly, cut-off threshold can be reversibly adjusted by temperature control. Therefore, provide molecule-selective encapsulation controlled release enca...

Permeation of the cell membrane leading to cell death is a mechanism used by a large number of membrane-lytic peptides. Some are linear, mostly helical, and others contain one or more disulfide bonds forming beta-sheet or both beta-sheet and alpha-helix structures. They are all soluble in solution but when they reach the target membrane, conformational changes occur which let them associate wit...