Introduction: Sialic acid plays pivotal roles in various critical physiological events at molecular and cellular levels and also pathological processes. Changes in sialic acid concentration are observed in many pathological processes; for example, there are some available data on the evaluated level of sialic acid and neurodegenerative prevalence. It can be proposed that sialic acid can play a ...

background: detection of cancer at an early stage is of utmost importance to decrease the morbidity and mortality of the disease. apart from the conventional biopsy, non‑invasive methods like analysis of serum and saliva may provide cost‑effective approach for screening a large population. tumor markers are a major part of secondary prevention and thus, the detection of malignancies. the aim of...

Previous studies have shown that epididymal epithelium and its secretions are critical for sperm maturation. These secretions contain many glycoconjugates with sialic acid terminal sugar. This terminal sugar by interveining in cellular interactions and masking surface receptors, has an important role in sperm maturation and protection. Moreover lectins have been employed as useful probes to det...

background: oral squamous cell carcinoma (oscc) is one of the most common malignant tumors. its incidence is rated as one among the highest in the world and the use of tobacco in various forms is increasingly associated with the cause of oscc. in oral cancer the study of tumor markers have been limited and several tumor makers with clinical promise needs further evaluation. methods: present stu...

conclusions salivary free and total sialic acid, and total protein were higher in the paan consumers compared to non-consumers. due to the carcinogenic effect of smokeless tobacco, measurement of these parameters in saliva may be useful in early detection of oral cancer. results the concentration of salivary free sialic acid (23.21 ± 18.98 mg/l) was significantly increased in paan consumers. th...

hereditary inclusion body myopathy (hibm) is an adult-onset hereditary myopathy, usually with distal onset and quadriceps sparing. this myopathy is autosomal recessive and associated to upd-n-acetylglucosamine-2-epimerase/n-acetylmannosamine kinase (gne) gene mutations. in this study, we report a novel gne homozygous point mutation c.1834t>g that results in amino acid substitution of cysteine 6...

two sialic acid specific lectins episesarma tetragonum agglutinin–1 and 2 were purified from the hemolymph of the mangrove crab, episesarma tetragonum . the major lectin was purified using cnbr-activated sepharose 4b conjugated to fetuin. n-acetyl glucosamine containing buffer was used for elution. the hemagglutination activity of purified lectin was inhibited by glycoproteins containing siaα, ...

BACKGROUND Milk is the sole source of nutrients for neonatal mammals and is generally considered to have co-evolved with the developmental needs of the suckling newborn. One evolutionary conserved constituent of milk and present on many glycoconjugates is sialic acid. The brain and colon are major sites of sialic acid display and together with the liver also of synthesis. METHODOLOGY/PRINCIPA...

Sialic acid (Neu5Ac, 1), a constituent of sialoglycoproteins1 and gangliosides,2 mediates a number of intercellular and cell-virion recognition events.3 Analogs of sialic acid are interesting as potential inhibitors for medicinally important target proteins, such as neuraminidase of the influenza virus.4 The syntheses of sialic acid and its analogs have been the subject of extensive research.5 ...

Infection by Aspergillus fumigatus, which causes the life-threatening disease invasive aspergillosis, begins with the inhalation of conidia that adhere to and germinate in the lung. Previous studies have shown that A. fumigatus conidia express high levels of the negatively charged 9-carbon sugar sialic acid, and that sialic acid appears to mediate the binding of A. fumigatus conidia to basal la...