نتایج جستجو برای: Small interfering
تعداد نتایج: 801665 فیلتر نتایج به سال:
in this study, several designed creb1-specific shrnas cloned into lentiviral transfer vectors were screened in293t by transient transfection assays. relative creb1 expression was determined by relative qrt-pcr. all of the designed shrnas gave some level of knockdown. one shrna was more effective for knocking down the specific gene among others. the predicted sirnas activities as determined by r...
Gene silencing using RNAi (RNA interference), has recently been used as a successful laboratory technique in determining the function and control of gene expression and provides a wide range of applications in molecular biology and gene therapy. RNAi is a method of suppressing gene expression. In this direction, a single-stranded RNA molecule of about 21–23 nucleotides, called siRNA (small inte...
background angiogenesis is an important biological process involved in the proliferation of endothelial cells, tumor growth and metastasis. vascular endothelial growth factor (vegf) is considered as a prominent regulator of angiogenesis which exerts the aforementioned effect(s) through its respective receptors (vegfr1 and vegfr2). vegf receptors are targeted as a therapeutic candidate for cance...
Genuine, nondegraded PAMAM dendrimers self-assemble with siRNA into nanoscale particles that are efficient for siRNA delivery and induce potent endogenous gene silencing.
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