background some herbal anticancer agents have direct interactions with dna. objectives the present study aimed to investigate the interaction of ctdna with rosemary flowers. materials and methods we used uv-vis, fluorescence and circular dichroism (cd) spectroscopic techniques. results the absorption of dna at 260 nm increased on addition of rosemary. herb extract quench the fluorescence of etb...

the macrocyclic ligands 2,3,5,6-bis{3’-bromo-5’-tert-butyl benzo-5-phenyl benzo} 12c3 (l1), 2,3,5,6-bis{3’-bromo-5’-tert butyl-benzo-5’-phenyl-benzo}15c4 (l2), 2,3,5,6-bis{3’-bromo-5’-tert butyl-benzo-5’-phenyl-benzo}18c5 (l3) have been synthesized and their alkaline metal compounds with naclo4∙h2o and kclo4  have been prepared. chemical formulas of all compounds have been characterized by usin...

the dimerization constants of safranine t have been determined by studying the dependence of its absorption spectra on the temperature in the range 30–70 ◦c at different total concentrations of safranine t (1.03×10−5, 1.44×10−5 and 1.73×10−5 m). the monomer–dimer equilibrium of safranine t has been determined by applying mcr-als method on the absorption spectra. the quantitative analysis of the...

in order to represent the potential energy function over the whole range of r, many potentialenergy functions have been proposed. in the present paper, we employ many potential energyfunctions, to use numerov method for solving the nuclear schrödinger equation for the ifmolecule, as an example of a heteronuclear diatomic molecules. then we determine thespectroscopic constants eω , e e x ω , e b...

a novel quaternary ammonium-based cationic gemini surfactant (s6) having 1,6 di-bromo hexane as a spacer, have been used and its interaction with insulin in aqueous solution (ph, 7.40) was investigated by several methods including fluorescence spectroscopy, uv-vis spectroscopy, circular dichroism, dynamic light scattering, ζ-potential measurements, conductivity and transmission electron microsc...

human serum albumin (hsa) is an important protein that carries variety of substances like some hormones and drugs in blood. pharmacological studies of the interaction of many drugs and hsa are reported during several decades, specially recently years. interaction of cortisol and fluoxetine hydrochloride (flx) (as a common anti-stress drug) with hsa (as their carrier in blood) has been studied s...

background: infectious diarrhoea is an emergent problem in both developing and developed countries for high rates of mortality in infants. in recent years, drug resistance to microbial pathogens has been commonly reported from all over the world. medicinal plants represent a rich source of antimicrobial agents. plants are used medicinally in different countries especially in india and are a sou...

the interactions between platinum complexes and human serum albumin (hsa) play crucial roles in the distribution, metabolism, and activity of platinum-based anticancer drugs. octahedral platinum (iv) complexes represent a significant class of anticancer agents that display molecular pharmacological properties different from cisplatin. in this study, the interaction between two pt(iv) complexes ...