the deleterious effects of morphine sulphate addiction on the central nervous system are welldocumented. previous studies have shown that the passage of morphine from the placenta barrier caninfluence the normal development of embryos, such as those of humans, by specific mechanisms. so, forthe first time, for the purpose of investigating the effects of morphine sulphate on pregnant animals,thr...

Anti-apoptotic and antioxidant effects of melatonin protect spleen whole body ?-irradiated male Sprague-dawley rats

Male and female Sprague-Dawley rats reared in social isolation and in crowded conditions were tested on their active-avoidance performance. Only males appeared to be affected by the treatments; no housing-condition effect was found on the performance of females. The most severe housing-condition effect was that of social isolation; the isolated males showed impaired acquisition of the avoidance...

Male Sprague-Dawley rats ranging in age from 20 to 110 days were injected with two doses of morphine sulphate, and examined for behavioral activation and catalepsy. Behavioral activation increased with age, while sensitivity to catalepsy declined. Ontogenetic and pharmacological responses suggest possible separate mediation of activation and catalepsy.

The purpose of this study is to evaluate the acute oral toxicity Turmeric based herbal product in sprague dawley rats. Acute refers those adverse effects occurring following administration a single dose substance, or multiple doses given within 24 hours. LD50 value, defined as statistically derived that, when administered an test, expected cause death 50% treated animals period, currently basis...

RATIONALE MDMA alters body temperature in rats with a direction that depends on the ambient temperature (TA). The thermoregulatory effects of MDMA and TA may affect intravenous self-administration (IVSA) of MDMA but limited prior reports conflict. OBJECTIVE To determine how body temperature responses under high and low TA influence MDMA IVSA. METHODS Male Sprague-Dawley rats were trained to...

The aim of this study was to determine whether the time of day ceftriaxone was administered modified its pharmacokinetics. Ceftriaxone was given intraperitoneally at either 0400, 1000, 1600, and 2200 h to Sprague-Dawley rats synchronized under a light-dark cycle of 12 h of light and 12 h of dark. Pharmacokinetic parameters were analyzed for the presence of a 24-h rhythm. Results showed signific...

Human drug experimentation begins during late childhood and early adolescence, a critical time in physical and CNS development, when the immature CNS is vulnerable to the long-term effects of psychoactive drugs. Few preclinical animal studies have investigated responses to such drugs in a developmental stage equivalent to late childhood of humans. We used a rodent model to examine behavioral re...

Earlier we reported that in a number of experiments pineal melatonin production in rats under constant laboratory conditions displayed seasonal rhythms but subsequently were not always able to confirm this. Since there was no indication under which conditions such rhythms may be present, we performed four consecutive identical experiments with untreated female Sprague-Dawley rats within the sam...