Introduction: The dorsal striatum plays an important role in the control of motor activity and learning processes within the basal ganglia circuitry. Furthermore, recent works have suggested functional differentiation between subregions of the dorsal striatum Methods: The present study examined the effects of bilateral electrolytic lesions of the dorsomedial striatum on motor behavior and learn...

introduction: the dorsal striatum plays an important role in the control of motor activity and learning processes within the basal ganglia circuitry. furthermore, recent works have suggested functional differentiation between subregions of the dorsal striatum methods: the present study examined the effects of bilateral electrolytic lesions of the dorsomedial striatum on motor behavior and learn...

the study aimed to investigate the protective effects of crocin (cro) against streptozotocin (stz)-induced oxidative damage in rat striatum. animals were randomly divided into four groups (five each). group 1 (sham) were treated with normal saline (2 ml/kg, p.o.). group 2 (stz-lesioned or lesion) were injected with icv-stz (3 mg/kg bilaterally, on day 1 and 3) and treated with normal saline (2 ...

from april 2009 to december 2011, 44 dead hedgehogs (erinaceus europaeus) were collected incidentally from areas of urmia, iran. the overall prevalence of helminth infections was 95.0%. specific parasites and their prevalences were: physalopteraclausa(93.0%), crenosoma striatum (61.0%), capillariaaerophila(9.0%), capillariasspp.(4.0%), brachylaemuserinacei(2.0%) and hymenolepiserinacei(16.0%). ...

Depressive disorder will be the second highest disease burden worldwide, which will impair life quality, reduce productivity, and increase disability and mortality. LBP is the main active fraction purified from Lycium barbarum. The aim of this study was to evaluate the potential therapeutic effects of LBP on depressive mice induced by reserpine, as well as the relevant mechanisms. The antidepre...

Depressive disorder will be the second highest disease burden worldwide, which will impair life quality, reduce productivity, and increase disability and mortality. LBP is the main active fraction purified from Lycium barbarum. The aim of this study was to evaluate the potential therapeutic effects of LBP on depressive mice induced by reserpine, as well as the relevant mechanisms. The antidepre...

The properties of microglia largely differ depending on aging as well brain regions. However, there are few studies that investigated the functional importance such heterogeneous at molecular level. Voltage-gated proton channel, Hv1/VSOP, could be one candidates which confers heterogeneity among since it regulates oxidative stress in age-dependent manner. In this study, we found Hv1/VSOP shows ...

The G9a/G9a-like protein (GLP) histone lysine dimethyltransferase complex and downstream H3 9 dimethylation (H3K9me2) repressive mark have recently emerged as key transcriptional regulators of gene expression programs necessary for long-term memory (LTM) formation in the dorsal hippocampus. However, role hippocampal G9a/GLP mediating consolidation spatial LTM remains largely unknown. Using a wa...

The entopeduncular nucleus is one of the basal ganglia's output nuclei, thereby controlling ganglia information processing. Entopeduncular neurons integrate GABAergic inputs from Striatum and globus pallidus, together with glutamatergic subthalamic nucleus. We show that endocannabinoids dopamine interact to modulate long-term plasticity all these primary afferents Our results suggest interplay ...

Associating spatial locations with rewards is fundamental to survival in natural environments and requires the integrity of the hippocampus and ventral striatum. In joint multineuron recordings from these areas, hippocampal-striatal ensembles reactivated together during sleep. This process was especially strong in pairs in which the hippocampal cell processed spatial information and ventral str...