نتایج جستجو برای: T3SS Mutant

تعداد نتایج: 130181  

Journal: :Frontiers in sustainable food systems 2022

Bacterial fruit blotch (BFB) caused by Acidovorax citrulli is a worldwide threat to watermelon and melon production. The type III secretion system (T3SS) plays an important role in the virulence of A. its host plants induce hypersensitive response (HR) non-host plants. Little known, however, about contribution T3SS biofilm formation . We mutated two T3SS-related genes hrcJ hrpE , respectively, ...

Journal: :Journal of bacteriology 2004
Weihui Wu Hassan Badrane Shiwani Arora Henry V Baker Shouguang Jin

The type III secretion system (T3SS) of Pseudomonas aeruginosa is an important virulence factor. The T3SS of P. aeruginosa can be induced by a low calcium signal or upon direct contact with the host cells. The exact pathway of signal sensing and T3SS activation is not clear. By screening a transposon insertion mutant library of the PAK strain, mutation in the mucA gene was found to cause repres...

Journal: :Avian pathology : journal of the W.V.P.A 2009
Shuhui Li Zhenyu Zhang Lanny Pace Hyun Lillehoj Shuping Zhang

Salmonella enterica serovar Enteritidis (SE) infection of chickens is a major contributing factor to non-typhoidal salmonellosis. The roles of the type-three secretion systems (T3SS-1 and T3SS-2) in the pathogenesis of SE infection of chickens are poorly understood. In this study, the functions of T3SS-1 and T3SS-2 during SE infection of primary chicken oviduct epithelial cells (COEC) and macro...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2013
Shin Okazaki Takakazu Kaneko Shusei Sato Kazuhiko Saeki

Root-nodule symbiosis between leguminous plants and nitrogen-fixing bacteria (rhizobia) involves molecular communication between the two partners. Key components for the establishment of symbiosis are rhizobium-derived lipochitooligosaccharides (Nod factors; NFs) and their leguminous receptors (NFRs) that initiate nodule development and bacterial entry. Here we demonstrate that the soybean micr...

2013
Yi-Hu Dong Xi-Fen Zhang Lian-Hui Zhang

The opportunistic pathogen Pseudomonas aeruginosa utilizes type III secretion system (T3SS) to translocate effector proteins into eukaryotic host cells that subvert normal host cell functions to the benefit of the pathogen, and results in serious infections. T3SS in P. aeruginosa is controlled by a complex system of regulatory mechanisms and signaling pathways. In this study, we described that ...

Journal: :Infection and immunity 2013
Andrew S Houppert Lesley Bohman Peter M Merritt Christopher B Cole Adam J Caulfield Wyndham W Lathem Melanie M Marketon

Yersinia pestis, the causative agent of plague, uses a type III secretion system (T3SS) to inject cytotoxic Yop proteins directly into the cytosol of mammalian host cells. The T3SS can also be activated in vitro at 37°C in the absence of calcium. The chromosomal gene rfaL (waaL) was recently identified as a virulence factor required for proper function of the T3SS. RfaL functions as a ligase th...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2014
Jeffrey C Anderson Ying Wan Young-Mo Kim Ljiljana Pasa-Tolic Thomas O Metz Scott C Peck

Genes encoding the virulence-promoting type III secretion system (T3SS) in phytopathogenic bacteria are induced at the start of infection, indicating that recognition of signals from the host plant initiates this response. However, the precise nature of these signals and whether their concentrations can be altered to affect the biological outcome of host-pathogen interactions remain speculative...

Journal: :Infection and immunity 2007
Mark L Urbanowski Evan D Brutinel Timothy L Yahr

Transcription of the Pseudomonas aeruginosa type III secretion system (T3SS) is induced under Ca(2+)-limiting growth conditions or following the contact of the bacteria with host cells. The regulatory response to low Ca(2+) levels is initiated by the T3SS-mediated secretion of ExsE, a negative regulatory protein that prevents T3SS gene transcription. In the present study, we demonstrated that E...

2014
Suely C. F. Sampaio Fabiana C. Moreira Ana M. A. Liberatore Mônica A. M. Vieira Terezinha Knobl Fabiano T. Romão Rodrigo T. Hernandes Claudete S. A. Ferreira Antônio P. Ferreira Aloísio Felipe-Silva Rita Sinigaglia-Coimbra Ivan H. J. Koh Tania A. T. Gomes

Atypical enteropathogenic Escherichia coli (aEPEC) inject various effectors into intestinal cells through a type three secretion system (T3SS), causing attaching and effacing (A/E) lesions. We investigated the role of T3SS in the ability of the aEPEC 1711-4 strain to interact with enterocytes in vitro (Caco-2 cells) and in vivo (rabbit ileal loops) and to translocate the rat intestinal mucosa i...

2012
Marlies Galle Shouguang Jin Pieter Bogaert Mira Haegman Peter Vandenabeele Rudi Beyaert

The type III secretion system (T3SS) is a complex nanomachine of many pathogenic gram-negative bacteria. It forms a proteinaceous channel that is inserted into the host eukaryotic cell membrane for injection of bacterial proteins that manipulate host cell signaling. However, few studies have focused on the effector-independent functions of the T3SS. Using a murine model of acute lung infection ...

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