INTRODUCTION The rise in antimicrobial resistance is a major global concern and requires new treatment strategies. The use of helper compounds, such as thioridazine (TDZ), an antipsychotic drug, in combination with traditional antibiotics must be investigated. OBJECTIVES The aim of this study was to investigate the efficacy of TDZ as a helper compound for dicloxacillin (DCX) against methicill...

Subinhibitory concentrations of the neuroleptic drug thioridazine (TDZ) are well-known to enhance the killing of methicillin-resistant Staphylococcus aureus (MRSA) by β-lactam antibiotics, however, the mechanism underlying the synergy between TDZ and β-lactams is not fully understood. In the present study, we have examined the effect of a subinhibitory concentration of TDZ on antimicrobial resi...

INTRODUCTION Conservative treatment solutions against aortic prosthetic vascular graft infection (APVGI) for inoperable patients are limited. The combination of antibiotics with antibacterial helper compounds, such as the neuroleptic drug thioridazine (TDZ), should be explored. AIM To investigate the efficacy of conservative systemic treatment with dicloxacillin (DCX) in combination with TDZ ...

Leaf yellowing or petal senescence is the main postharvest disorder for many cut flowers. Plant hormones such as cytokinins are able to inhibit leaf yellowing in some cut flowers and potted plants. In our experiments, we applied thidiazuron aiming to delay leaf yellowing and 1-methylciclopropene (1-MCP) for inhibiting flower senescence of cut stock flowers during vase life. Cut flowers were pul...

A simple and highly sensitive electrochemical method based on a 1,4-benzoquinone modified carbon paste electrode (1,4-BQMCPE) was described for the determination of tinidazole (TDZ). In Britton Robinson buffer solution, TDZ yields well-defined irreversible reduction peak at -0.344 V on a 1,4-BQMCPE. Compared with that on a bare CPE, the reduction peak of TDZ increased significantly on the modif...

Melia volkensii Gurke is a drought-tolerant tree native to East Africa's arid and semiarid lands (ASALs), with vast but underutilized potential for agroforestry and sustainable livelihoods in the ASALs. Its cultivation is limited by difficulties in propagation via conventional means. Full exploitation of the ability of thidiazuron (TDZ) to elicit regeneration in plant tissue cultures, as sole p...

The effect of 2, 4-D and TDZ concentrations on primary embryogenesis seem to be genotype dependent. There were significant differences between the control and the other treatments on somatic embryo production by genotype AMAZ 3-2. Genotype COCA 3370-5 did not show any significant difference among the treatments with 1mg/l 2, 4-D + 1μg/l TDZ, 1mg/l 2,4-D + 10μg/l TDZ and the control treatment. T...

Thioridazine (TDZ), originally an anti-psychotic drug, suppresses several types of cancer and has specificity for leukemia stem cells. The present study was performed to assess its effect on lung cancer stem-like cells, as its effect remains unknown. TDZ was utilized to treat lung cancer stem-like cells (A549 sphere cells) and its cytotoxic effect and mechanism were evaluated in vitro and in vi...

Morphogenic potential of cabbage cv. Pride of India, for multiple shoot induction was tested under in vitro conditions using cotyledon and hypocotyl explants. Aseptically grown seven to nine days old seedlings of cabbage were used as source of explants for reproducible plant regeneration studies. Forty different concentrations and combinations of TDZ (alone), TDZ with adenine, TDZ with NAA and ...

In the plant regeneration process, a great deal of variability is observable between different varieties and genotypes. Even within the same genotype, there are differences in the intensity of this process. New biologically active substances are currently being tested to increase the effectiveness of regeneration in plants. Among them are zearelonene (ZEN) – a substance obtained from an extract...