نتایج جستجو برای: TGF-β1
تعداد نتایج: 34371 فیلتر نتایج به سال:
Background: Mesenchymal stem cells (MSCs) and transforming growth factor-β1 (TGF-β1) molecules are well known for their immunomodulatory properties and their function in tissue regeneration and remodeling. Objectives: To evaluate the interaction of TGF-β1 engineered MSCs with T cells and dendritic cells (DCs) and their modulatory effect on the immune response. Methods: MSCs and DCs were generat...
idiopathic chronic urticaria (icu), the most common form (70-80%) of chronic urticaria is supposed to have immune basis causes. it is speculated that the promoter polymorphism of tgf-β1 gene may be involved in icu. this condition is thought to affect at least 0.1% of the population and often can be severe and difficult to treat. a total of 40 patients with icu and 41 normal subjects were studie...
Background: Successful pregnancy in allopregnant women depends upon the control of graft rejection mechanisms. It has been suggested that some immunosuppressive cytokines contribute to successful pregnancy and transplantation. Transforming growth factor beta (TGF- β) exhibits potent immunoregulatory and anti-inflammatory properties which might prolong graft survival. Recent studies suggest a ...
background: successful pregnancy in allopregnant women depends upon the control of graft rejection mechanisms. it has been suggested that some immunosuppressive cytokines contribute to successful pregnancy and transplantation. transforming growth factor beta (tgf- β) exhibits potent immunoregulatory and anti-inflammatory properties which might prolong graft survival. recent studies suggest a ...
Objective(s): To investigate and test the hypotheses that TGF-β1 enhanced myocardial differentiation through Wnt/β-catenin pathway with rat bone marrow mesenchymal stem cells (BMSCs).Materials and Methods: Lentiviral vectors carrying the TGF-β1 gene were transduced into rat BMSCs firstly. Then several kinds of experimental methods were u...
background: normal tissue toxicity continues to remain as a major challenge for radiation oncologists for delivering the total dose to the tumour cells in cancer patients. cellular, molecular and plasma based early biomarkers to predict the overreactions and non-overreactions of normal tissue toxicity before the initiation of radiotherapy can be valuable for personalised treatment. the aim of t...
background: transforming growth factor-β1 (tgf-β1) has been found to play a crucial role in early central nervous system development. several studies have illustrated decreased tgf-β1 levels in sera and brains of autistic children. two point mutations in the tgf-β1 signal peptide at 869t/c and 915g/c have been reported to influence tgf-β1 expression. the aim of the present study was to investig...
Background and Aim: As a blistering agent, mustard gas causes a variety of disorders in different body organs, including the skin, such as altrations in DNA and clinical manifestations like pruritus. TGF-β1 molecule is a cytokine with anti-cell growth and inflammation suppression effects in skin inflammation. The aim of this study was to determine TGF-β1 gene exprtession in victims exposed to m...
Background: Multiple studies have examined the potential of growth factors (GF) to enable mesenchymal stromal cells (MSC) nucleus pulposus (NP) cell-like cell differentiation. Here we screened a wide range GF and combinations for supporting NP Methods: Human MSC were stimulated using 86 different TGF-β1, -2, -3, GDF5, -6, Wnt3a, -5a, -11, Shh. Differentiation potency was assessed by alcian blue...
سابقه و هدف: TGF-β1 یکی از فاکتورهای رشد است که در کنترل عملکرد سلولی در هر دو حالت سلامت و بیماری نقش دارد. اما چگونگی اثر سیگار بر سطح و غلظت این سایتوکاین در مایع شیار لثهای، همچنان ناشناخته باقی مانده است. هدف از این مطالعه بررسی رابطه مصرف سیگار با غلظت TGF-β1 موجود در مایع شیار لثهای در بیماران مبتلا به پریودنتیت مزمن متوسط تا شدید بود. مواد و روشها: در مطالعه تحلیلی و مورد-شاهدی حاض...
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