Methods and materials All patients underwent a single-injection of FDG, followed first by PET-CT and subsequently by PET-MRI scan. The PET/CT exams were performed using a GE Discovery 690 PET/CT scanner. The PET/MRI images were acquired on a GE Signa PET/MRI scanner. All PET images were reconstructed with and without the TOF data. Visual analysis of these series was performed for dental metal /...

After a brief review of the history of time-of-flight (TOF) positron emission tomography (PET) instrumentation from the 1980s to present, the principles of TOF PET are introduced, the concept of time resolution and its effect on TOF gain in signal-to-noise ratio (SNR) are discussed. The factors influencing the time resolution of a TOF PET scanner are presented, with focus on the intrinsic prope...

Time-of-flight (TOF) positron emission tomography (PET) technology has recently regained popularity in clinical PET studies for improving image quality and lesion detectability. Using TOF information, the spatial location of annihilation events is confined to a number of image voxels along each line of response, thereby the cross-dependencies of image voxels are reduced, which in turns results ...

GE Healthcare, USA In a functional PET/MR study, it is difficult to get good temporal resolution of activity distribution from PET images because of the need to image for a certain length of time to get sufficient count statistics (image SNR). Time-of-flight (TOF) reconstruction can be used to increase PET images SNR and therefore increase the temporal resolution. Five patients were injected wi...

Stanford University, USA A time-of-flight (TOF)-PET/MR research system installed at Stanford will be used to test the hypotheses that (a) it is possible to acquire simultaneous TOF-PET and 3T MR data while achieving uncompromised performance in both modalities and (b) simultaneous TOF-PET/MR is a tool for multi-parameter characterization of disease. In this paper we will describe the design as ...

PURPOSE To evaluate the possible activity reduction in FDG-imaging in a Time-of-Flight (TOF) PET/MR, based on cross-evaluation of patient-based NECR (noise equivalent count rate) measurements in PET/CT, cross referencing with phantom-based NECR curves as well as initial evaluation of TOF-PET/MR with reduced activity. MATERIALS AND METHODS A total of 75 consecutive patients were evaluated in t...

Objective(s): The present study was conducted to examine whether the standardized uptake value (SUV) may be affected by the spatial position of a lesion in the radial direction on positron emission tomography (PET) images, obtained via two methods based on time-of-flight (TOF) reconstruction and point spread function (PSF). Methods: A cylinder phantom with the sphere (30mm diameter), located in...

Recent technical advances in positron emission tomography/magnetic resonance imaging (PET/MRI) technology allow much improved time-of-flight (TOF) and regularized iterative PET reconstruction regularized iterative reconstruction (RIR) algorithms. We evaluated the effect of TOF and RIR on standardized uptake values (maximum and peak SUV [SUVmax and SUVpeak]) and their metabolic tumor volume depe...