Aim. To investigate pharmacological mechanisms of Wu Tou Tang acting on rheumatoid arthritis (RA) by integrating network analysis at a system level. Methods and Results. Drug similarity search tool in Therapeutic Targets Database was used to screen 153 drugs with similar structures to compositive compounds of each ingredient in Wu Tou Tang and to identify 56 known targets of these similar drugs...

Time-of-Use (ToU) electricity pricing is an electricity pricing scheme where consumers are charged at a rate that is dependent on the time of electricity consumption. This pricing scheme is often implemented to match the cost of generating and supplying electricity, and to make consumers defer appliance usage; this would reduce the daily electricity consumption peak that can both reduce the cos...

This paper studies the impact of Time-Of-Use (TOU) tariffs in a competitive electricity market place. Specifically, it focuses on the question of how should an autonomous broker agent optimize TOU tariffs in a competitive retail market, and what is the impact of such tariffs on the economy. We formalize the problem of TOU tariff optimization and propose an algorithm for approximating its soluti...

The GATA factor Pannier (Pnr) activates proneural expression through binding to a remote enhancer of the achaete-scute (ac-sc) complex. Chip associates both with Pnr and with the (Ac-Sc)-Daughterless heterodimer bound to the ac-sc promoters to give a proneural complex that facilitates enhancer-promoter communication during development. Using a yeast two-hybrid screening, we have identified Tout...

Analyzing the impact of pricing policies such as time-of-use (TOU) is challenging in the presence of confounding factors such as weather. Motivated by a lack of consensus and model selection details in prior work, we present a methodology for modelling the effect of weather on residential electricity demand. The best model is selected according to explanatory power, out-of-sample prediction acc...

Electric vehicles (EVs) and the related infrastructure are being developed rapidly. In order to evaluate the impact of factors on the aggregated EV load and to coordinate charging, a model is established to capture the relationship between the charging load and important factors based on data mining. The factors can be categorized as internal and external. The internal factors include the EV ba...

Customer-owned battery energy storage systems (BESS) have been used to reduce electricity costs of energy storage owners (ESOs) under a time-of-use (TOU) tariff in Korea. However, the current TOU tariff can unintentionally induce customer’s electricity usage to have a negative impact on power systems. This paper verifies the impact of different BESS operation strategies on power systems under a...

This paper determines the optimal capacity of solar photovoltaic (PV) and battery energy storage (BES) with novel rule-based management systems (EMSs) under flat time-of-use (ToU) tariffs. Four schemes are investigated based on combinations ToU tariffs for buying selling electricity: (1) Flat-Flat, (2) ToU-Flat, (3) Flat-ToU, (4) ToU-ToU. For each scheme, two configurations evaluated: (i) PV on...

The efficient reduction of GHG emissions requires appropriate retail pricing of off-peak electricity. However, off-peak electricity for residential consumers is priced at 331% above its marginal cost in the United States as a whole (June 2009). Even for the 1% of residences that are on some form of time-ofuse (TOU) rate schedule, the off-peak rate is almost three times higher than the marginal ...

A 73-year-old woman developed subacute meningitis-retention syndrome (MRS), dermatitis, and latent pneumonitis likely due to the herbal medicines Shinbu-Tou and Rikkunshi-Tou. The responsible site of lesions for urinary retention seemed to be the spinal micturition pathways and, to a lesser extent, the sacral spinal cord. All of her clinical manifestations were successfully ameliorated within t...