Cadmium (Cd) is being frequently detected in marine organisms. However, dose-dependent effects of Cd challenged unraveling the toxicological mechanisms to organisms and developing biomarkers. Here, on clams Ruditapes philippinarum following exposure 5 doses (3, 9, 27, 81, 243 μg/L) were investigated using benchmark dose (BMD) method. By model fitting, calculation BMD values was performed transc...

BACKGROUND/AIMS Low ambient temperature is an important risk factor for cardiovascular diseases, and has been shown to lead to cardiac hypertrophy. In this study, we aim to investigate if Resveratrol may inhibit cold exposure-induced cardiac hypertrophy in mice, and if so to clarify its molecular mechanism. METHODS Adult male mice were randomly assigned to Control group (kept at room temperat...

Background: Varicocele occurs in approximately 15 to 20% of the general male population and it is the most common cause of poor semen production and decreased semen quality. It has been demonstrated that patients with varicocele have a significantly higher DNA damage and spermatozoa with nuclear anomalies than healthy men. Previously it was documented that antioxidant therapy or varicocelectomy...