Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) which causes demyelination of the nerve fibers. The etiology of this disease is not well understood but it is believed that T helpers play a central role in MS. Numerous findings support the view that Th17 cells play an essential role in pathogenesis of MS and IL-17 secreting T (Th17) cells have a role in infla...

Background: Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by T-cells imbalance. There are ongoing controversies about the role of specific T-helper cell subsets and their cytokines. The study aimed to confirm the disturbance of Th17/Treg ratio in SLE patients. Methods: Subjects were SLE patients who met the American College of Rheumatology 1997 criteria. Dis...

T lymphocytes that are involved in cellular mediated immunity include two types known as TCD8+ (Cytotoxic T lymphocytes) and TCD4+ (helper T lymphocytes). TCD4+ has four main subtypes, including TH1, TH2, TH17, and Treg Lymphocytes.TH17 lymphocytes play a role in defense against microbes that TH1 and TH2 lymphocytes have not the ability to respond to them. The most important cytokines, which ar...

interleukin (il)-17-producing t helper (th)-17 cells have recently been explained as a distinct population  of  cd4+  t  cells which play an important  role in immunity against infectious agents. establishment of persistent phenotype of th17 cells and recognition of lineage-deviating factors are of most attractive goals in modern researches in immunology. although  il-6  and  tgf-β  are  freque...

Objective(s): Here we investigated the regulation of Th17 and Treg cells in orthodontic tooth movement during periodontal inflammation.Materials and Methods: Fifty-six SD rats were divided into a control (24 rats) and a tooth movement group during the recovery stage of periodontitis (RM group, 32 rats). Periodontitis was established by s...

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Objective(s): This study aimed to investigate the role and the possible mechanisms involved in the immunoregulation of experimental periodontitis by Th17/Treg. Materials and Methods: Experimental periodontitis was established by silk thread ligation with Porphyromonasgingivalis daubing in the bilateral maxillary second molar of Male Sprague-Dawley (SD) rats. Alveolar bones were scanned by Micro...

Background: Lack of sufficient information on the mechanism of plasma exchange (PE) therapy in multiple sclerosis (MS), has limited this treatment to individual patients with severe relapses who have been refractory to other treatments. This is while PE is used very successfully as a first-line standard treatment in many other neuro-immune disorders. Recent data suggest that Treg/Th17 counterb...

multiple sclerosis (ms) is an autoimmune disease of the central nervous system (cns) which causes demyelination of the nerve fibers. the etiology of this disease is not well understood but it is believed that t helpers play a central role in ms. numerous findings support the view that th17 cells play an essential role in pathogenesis of ms and il-17 secreting t (th17) cells have a role in infla...