ownload sesquiterpene lactone dihydroartemisinin (DHA), a semisynthetic derivative of the herbal antimalaria rtemisinin, is cytotoxic to human tumor cells. Treatment of Jurkat T-lymphoma cells with DHA ina breakdown of the mitochondrial transmembrane potential, release of cytochrome c, activation of es, and DNA fragmentation indicative of apoptosis induction. Although the absence of FADD or e-8...

nloaded sarcomas are aggressive mesenchymal cancers with poor outcomes that exhibit remarkable histologic ity (there are five recognized subtypes). Currently, the mainstay of therapy for liposarcoma is surgical n because liposarcomas are often resistant to traditional chemotherapy. In light of the high mortality ated with liposarcoma and the lack of effective systemic therapy, we sought novel g...

nloaded regulated fibroblast growth factor (FGF) signaling has been implicated in the pathogenesis of human s. Aberrant activation of FGF receptor 2 (FGFR2) signaling, through overexpression of FGFR2 and/or its s, mutations, and receptor amplification, has been found in a variety of human tumors. We generated lonal antibodies against the extracellular ligand-binding domain of FGFR2 to address t...

This article describes the case of a 46-year-old female patient who had been treated with radiotherapy for cervical cancer. She developed actinic cystitis with frequent episodes of severe hematuria. She required repeated catheterization to manage urinary retention, blood transfusions and hospital admissions. Conservative measures and attempts to achieve hemostasis by cystoscopy were unsuccessfu...

ownload sesquiterpene lactone dihydroartemisinin (DHA), a semisynthetic derivative of the herbal antimalaria rtemisinin, is cytotoxic to human tumor cells. Treatment of Jurkat T-lymphoma cells with DHA ina breakdown of the mitochondrial transmembrane potential, release of cytochrome c, activation of es, and DNA fragmentation indicative of apoptosis induction. Although the absence of FADD or e-8...