نتایج جستجو برای Thioacetamide

تعداد نتایج: 435  

Journal: :Human & experimental toxicology 2011
Kyeong-Gue Kwak, Jing-Hua Wang, Jang-Woo Shin, Dong-Soo Lee, Chang-Gue Son,

Chunggan extract (CGX) is a hepatotherapeutic herbal formula which has been traditionally used for patients suffering from various hepatic disorders. This study aimed to elucidate antifibrotic effect and mechanisms of CGX in thioacetamide (TAA) model. Hepatic fibrosis was induced in 45 Sprague-Dawley rats by TAA (200 mg kg(-1), intraperitoneally [ip]) on twice per week for 12 weeks. CGX (100 or...

Journal: :The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2017
Murat Muhsin Muhip Harputluoğlu, İsmail Temel, Ulvi Demirel, Yüksel Seçkin, Murat Aladağ, Barış Otlu, Neşe Karadağ, Fatma Özyalın, Nilay Aydoğan, Engin Burak Selçuk,

BACKGROUND/AIMS Steroids have been shown to prevent intestinal oxidative stress. We investigated the effects of methylprednisolone on intestinal oxidative damage and bacterial translocation in thioacetamide-induced liver failure in rats. MATERIALS AND METHODS Group 1 (n=8) was the control group. In group 2 (n=8), the thioacetamide group, rats received 300 mg/kg intraperitoneal thioacetamide d...

2013
Azam Rezaei, Shahnaz ShekarForoush, Saeed Changizi Ashtiyani, Hydar Aqababa, Ali Zarei, Maryam Azizi, Hasan Yarmahmodi,

OBJECTIVE Liver is an important organ that is exposed to many oxidant and carcinogenic agents, thus antioxidant compounds are beneficial for liver health. Artemisia contains flavonoid compounds and anti-diabetic, antioxidant, and anti-inflammatory properties. Due to possessing terpene and sesquiterpene compounds, this plant has antioxidant properties. This study was done to investigate the effe...

Journal: :Physiological research 2014
E Koblihová, I Mrázová, Z Vernerová, M Ryska,

Acute liver failure (ALF) is a clinical condition with very high mortality rate. Its pathophysiological background is still poorly understood, which necessitates a search for optimal experimental ALF models with features resembling those of the human disorder. Taking into consideration reproducibility of induction of ALF, adequate animal size, cost of animals, the required time gap between insu...

2017
Mitsuhiko Abe, Takafumi Yoshida, Jun Akiba, Yu Ikezono, Fumitaka Wada, Atsutaka Masuda, Takahiko Sakaue, Toshimitsu Tanaka, Hideki Iwamoto, Toru Nakamura, Michio Sata, Hironori Koga, Akihiko Yoshimura, Takuji Torimura,

AIM To elucidate the role of STAT3 in hepatocarcinogenesis and biliary ductular proliferation following chronic liver injury. METHODS We investigated thioacetamide (TAA)-induced liver injury, compensatory hepatocyte proliferation, and hepatocellular carcinoma (HCC) development in hepatic STAT3-deficient mice. In addition, we evaluated TAA-induced biliary ductular proliferation and analyzed th...

2012
M Farjam, P Dehdab, F Abbassnia, D Mehrabani, N Tanideh, S Pakbaz, M H Imanieh,

BACKGROUND As a serious neuropsychiatric disease, hepatic encephalopathy (HE) is a clinical condition with several types regarding chronicity and clinical diversity that can develop as a complication of both acute and chronic liver failure. This study evaluates changes in thioacetamide (TAA)-induced acute hepatic encephalopathy (AHE) in rat as an animal model. METHODS Both genders of C57BL6, ...

2014
TASLEEM AKHTAR, NADEEM SHEIKH, MUDDASIR H. ABBASI, AFSHAN S. ABBAS,

Various serum proteins are synthesized in the liver. Their serum levels may reduce or elevate due to liver disorders. Thioacetamide (TAA) is a powerful hepatotoxicant, multiple protein systems have been revealed to be injured, counting those present in the mitochondrial respiration, endoplasmic reticulum, and stress response proteins. The study was conducted to evaluate the hepatoprotective pot...

Journal: :Toxicology 1996
L Fontana, E Moreira, M I Torres, M I Fernández, A Ríos, F Sánchez de Medina, A Gil,

To date, no attempt has been made to study alterations occurring in the amino acid profile in chronic models of thioacetamide-induced liver cirrhosis. In this work, changes in serum amino acids and proteins in rats with thioacetamide-induced liver cirrhosis are reported, together with changes in enzyme activities in the liver and serum. Seventeen female Wistar rats were used. Eight rats were gi...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2001
S K Ramaiah, U Apte, H M Mehendale,

Earlier studies have shown highly exaggerated mechanism-based liver injury of thioacetamide (TA) in rats following moderate diet restriction (DR) and in diabetes. The objective of the present study was to investigate the mechanism of higher liver injury of TA in DR rats. Since both DR and diabetes induce CYP2E1, we hypothesized that hepatic CYP2E1 plays a major role in the bioactivation-based l...

Journal: :International journal of clinical and experimental pathology 2014
Jing-Jing Cheng, Nai-Bin Yang, Liang Wu, Jia-Le Lin, Ge-Xin Dai, Jia-Yin Zhu,

The aim of this study was to elucidate the effects of zedoary turmeric oil (ZTO) on P450 activities (CYP1A2, CYP2C9, CYP2C19, CYP2B6, CYP2D6 and CYP3A4) in rats with liver cirrhosis induced by thioacetamide (TAA). For the induction of liver cirrhosis, rats were given TAA in their drinking water at a concentration of 0.03% for consecutive 5 weeks and then 0.04% for the next consecutive 5 weeks t...

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