نتایج جستجو برای: Thioredoxin Reductase

تعداد نتایج: 48195  

Journal: :iranian journal of basic medical sciences 0
seyed isaac hashemy department of biochemistry, faculty of medicine, mashhad university of medical sciences, mashhad, iran

the thioredoxin system, comprising thioredoxin (trx), thioredoxin reductase (trxr) and nadph, is one of the major cellular antioxidant systems, implicated in a large and growing number of biological functions. trx acts as an oxidoreductase via a highly conserved dithiol/disulfide motif located in the active site ( trp-cys-gly-pro- cys-lys-). different factors are involved in the regulation of t...

Journal: :molecular biology research communications 0
mitra roodgar department of biotechnology, college of agriculture, isfahan university of ‎technology, isfahan, iran.‎ azar shahpiri department of biotechnology, college of agriculture, isfahan university of ‎technology, isfahan, iran.‎

thioredoxins (trxs) are small ubiquitous oxidoreductase proteins with two redox-active cys residues in a conserved active site (wcg/ppc) that regulate numerous target proteins via thiol/disulfide exchanges in the cells of prokaryotes and eukaryotes. the isoforms ostrx23 with a typical active site (wcgpc) and ostrx20 with an atypical active site (wctpc) are two  trx h- type isoforms in rice that ...

A set of Xanthohumol derivatives were selected and molecular docking studies of these ‎compounds on thioredoxin reductase were conducted. Based on new structural patterns using in ‎silico-screening study, new potent lead compounds were designed. The results due to validated ‎docking protocols lead to find that Thr58, Gly57, Gly21, Asp334, Glu163, Ala130, IIe332, ‎Val44 and Gly132 are the main a...

Journal: :The Biochemical journal 2003
Renée Kern Abderrahim Malki Arne Holmgren Gilbert Richarme

Thioredoxin, thioredoxin reductase and NADPH form the thioredoxin system and are the major cellular protein disulphide reductase. We report here that Escherichia coli thioredoxin and thioredoxin reductase interact with unfolded and denatured proteins, in a manner similar to that of molecular chaperones that are involved in protein folding and protein renaturation after stress. Thioredoxin and/o...

2010
Kornelia Edes Pamela Cassidy Paul J. Shami Philip J. Moos

BACKGROUND The selenoenzyme thioredoxin reductase 1 has a complex role relating to cell growth. It is induced as a component of the cellular response to potentially mutagenic oxidants, but also appears to provide growth advantages to transformed cells by inhibiting apoptosis. In addition, selenocysteine-deficient or alkylated forms of thioredoxin reductase 1 have also demonstrated oxidative, pr...

Journal: :Molecular cancer therapeutics 2006
Garth Powis Peter Wipf Stephen M Lynch Anne Birmingham D Lynn Kirkpatrick

The cytosolic thioredoxin redox system composed of thioredoxin-1 and the NADPH-dependent thioredoxin reductase-1 reductase is an important regulator of cell growth and survival. Thioredoxin-1 is overexpressed in many human tumors where it is associated with increased cell proliferation, decreased apoptosis, and decreased patient survival. We hypothesized that thioredoxin reductase-1 provides a ...

Journal: :The Journal of biological chemistry 1992
M Björnstedt S Kumar A Holmgren

Selenium compounds like selenite (SeO3(2-) may form a covalent adduct with glutathione (GSH) in the form of selenodiglutathione (GS-Se-SG), which is assumed to be important in the metabolism of selenium. We have isolated GS-Se-SG and studied its reactions with NADPH and thioredoxin reductase from calf thymus or with thioredoxin reductase and thioredoxin from Escherichia coli. Incubation of 0.1 ...

Journal: :Results in chemistry 2021

The thioredoxin system is vital in maintaining the cellular redox state and implicated various cancers other diseases. It comprises of reductase, NADPH. Various methods have been developed for detection quantification reductase enzyme. Most these suffer shortfall poor specificity, hence there need to develop more robust specific techniques. Recently, has an increased interest fluorescent probes...

2011
G. Kapoor

Thioredoxin reductase and glutathione reductase are important enzymes of redox system that help the malaria parasite to maintain an adequate intracellular redox environment and contribute greatly to the antioxidant capacity of the cell. In the present study humoral immune response directed against thioredoxin reductase and glutathione reductase during Plasmodium berghei infection were investiga...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2001
C Laloi N Rayapuram Y Chartier J M Grienenberger G Bonnard Y Meyer

Plants possess two well described thioredoxin systems: a cytoplasmic system including several thioredoxins and an NADPH-dependent thioredoxin reductase and a specific chloroplastic system characterized by a ferredoxin-dependent thioredoxin reductase. On the basis of biochemical activities, plants also are supposed to have a mitochondrial thioredoxin system as described in yeast and mammals, but...

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