INTRODUCTION The onset of atherosclerosis may be related to changes in vascular endothelial permeability to macromolecules, which may in turn be induced by wall shear stress or its related indices. We report here an initial experiment that correlates, site-by-site, the albumin uptake in a porcine aortic trifurcation with several measures of wall shear obtained by computational fluid dynamic (CF...

The effects of changes in flow velocity waveform and arterial geometry before and after percutaneous coronary intervention (PCI) in the right coronary artery (RCA) were investigated using computational fluid dynamics. An RCA from a patient with a stenosis was reconstructed based on multislice computerized tomography images. A nonstenosed model, simulating the same RCA after PCI, was also constr...

Numerical predictions of blood flow patterns and hemodynamic stresses in Abdominal Aortic Aneurysms (AAAs) are performed in a two-aneurysm, axisymmetric, rigid wall model using the spectral element method. Physiologically realistic aortic blood flow is simulated under pulsatile conditions for the range of time-averaged Reynolds numbers 50< or =Re(m)< or =300, corresponding to a range of peak Re...

Quantitative evaluation of shear stress in the vessel wall due to the presence of asymptomatic gas emboli is lacking. The goal of this work was to assess the impact of chronic asymptomatic gas emboli on the risk of atherosclerosis through a custom-built cardiovascular flow simulator. Gas bubbles were created by forced air from a syringe pump. The influences of embolism injection rate, pulse rat...

Clinically significant atherosclerosis in the human aorta is most common in the infrarenal segment. This study was initiated to test the hypothesis that flowfield properties are closely related to the localization of plaques in this segment of the arterial system. Wall shear stress was calculated from magnetic resonance velocity measurements of pulsatile flow in an anatomically accurate model o...

A severe case of stenosis in coronary arteries results in turbulence in the blood flow which may lead to the formation or progression of atherosclerosis. This study investigated the turbulent blood flow in a coronary artery with rigid walls, as well as 80% single and double stenoses on blood flow. A finite element-based software package, ADINA 8.8, was employed to model the blood flow. The hemo...

Recently, Mathis et al. (2011) developed a conceptual approach that is able to predict instantaneous wall-shear stress fluctuations in turbulent boundary layers. This approach embeds the scale interaction mechanisms, namely superposition and modulation, into a wall-model capable of predicting the fluctuating component of the streamwise wall-shear stress. The present study investigates the poten...

BACKGROUND AND PURPOSE Evolution of intracranial aneurysmal disease is known to be related to hemodynamic forces acting on the vessel wall. Low wall shear stress (WSS) has been reported to have a negative effect on endothelial cells normal physiology and may be an important contributor to local remodeling of the arterial wall and to aneurysm growth and rupture. METHODS Seven patient-specific ...

The present work focuses the study of wall shear stress-based descriptors: time averaged wall shear stress (TAWSS), oscillating shear index (OSI) and relative residence time (RRT), of sketch geometries of the left coronary artery (LCA): one healthy case, one disease case with 30% obstruction in the left anterior descending artery (LAD) and other disease case with 50% obstruction in the LAD. Mor...

In this study, a fluid-structure interaction analysis based on the application of patient-specific mechanical parameters of the aneurismal walls was carried out to predict the rupture side during an abdominal aortic aneurysm (AAA). Realistic geometry of the aneurysm was reconstructed from CT data acquired from the patient, and patient-specific flow conditions were applied as boundary conditions...