MOTIVATION To understand the molecular mechanisms of neurons, it is imperative to identify genomic dissimilarities within the heterogeneity of the neural system. This is especially true for neuronal disorders in which spatial considerations are of critical nature. For this purpose, Hirudo medicinalis provides here an ideal system in which we are able to follow gene expression along the central ...

In this paper we propose a new algorithm for solving multiobjective optimization problems. Our proposal adapts the well-known scatter search template for single objective optimization to the multiobjective domain. The result is a hybrid metaheuristic algorithm called AbYSS, which follows the scatter search structure but using mutation and crossover operators coming from the field of evolutionar...

MOTIVATION Whole transcriptome shotgun sequencing data from non-normalized samples offer unique opportunities to study the metabolic states of organisms. One can deduce gene expression levels using sequence coverage as a surrogate, identify coding changes or discover novel isoforms or transcripts. Especially for discovery of novel events, de novo assembly of transcriptomes is desirable. RESUL...