BACKGROUND Reference intervals are affected by different factors such as lifestyle, ethnicity, age/developmental stage, gender, nutrition and other environmental factors (Clin Biochem Rev: 29,2008). Therefore, it is obvious that it should be established for every population in different regions even within a country. Then the aim of this study is to establish population specific reference inter...

It is widely accepted that thyroid hormone replacement for patients with hypothyroidism can be fully accomplished with levothyroxine monotherapy, as assessed by serum thyroid function tests. However, approximately 10% of hypothyroid patients are dissatisfied with the outcome of levothyroxine monotherapy, and physicians continue to report benefits from combined levothyroxine-triidothyronine ther...

Triiodothyronine and thyroxine induce a 3-fold increase in the rate of growth of GH(1) cells in culture. To study further the action of these hormones, we examined the binding of [(125)I]triiodothyronine and purified [(125)I]thyroxine to cellular fractions after incubation with intact cells in serum-free medium. High-affinity, low-capacity binding sites for the hormones were demonstrated in nuc...

Thyroidectomy markedly reduces the oxidative capacity of rat liver mitochondria. After the injection of triidothyronine about half of the lost capacity is recovered within 3 hours. This rapid recovery is not associated with any change in the amounts of electron transport components, although the activities of cytochromes b and c are significantly increased by the hormone.

Diabetes mellitus (DM) is commonly associated with thyroid dysfunction. The aim of the present study was to evaluate the prevalence of thyroid dysfunction in subjects with type 2 diabetes and the effect of type 2 diabetes mellitus on other bio-chemical variables. In the present study 80 type 2 diabetic subjects and 80 healthy non diabetic subjects were investigated for total triidothyronine (T3...

Seasonal changes of the thyroid gland structure and hormones secretion was examined in yellowfin seabream Acanthopagrus latus in Persian Gulf (Zangi branch, Musa creek). Thyroid gland composed of follicles scattered around the ventral aorta, near the gills. Follicular cells varied according to secretion of the gland during warm and cold seasons. Thyroid hormones (Triidothyronine [T3] and Thyrox...

Triiodothyronine (T(3)) exerts direct action on myocardial oxygen consumption (MVO(2)), although its immediate effects on substrate metabolism have not been elucidated. The hypothesis, that T(3) regulates substrate selection and flux, was tested in isovolumic rat hearts under four conditions: control, T(3) (10 nM), epinephrine (Epi), and T(3) and Epi (TE). Hearts were perfused with [1,3-(13)C]a...