We developed a simplified method for quantitative measurement of trinitroglycerin in human plasma using hexane extraction and analysis by gas-liquid chromatography with electron-capture detection. This assay was linear from 0.5-60 ng/ml. Sensitivity and reproducibility were +/- 0.5 ng/ml. We used this assay to evaluate the pharmacodynamics of trinitroglycerin in 14 patients. Maximum plasma leve...

in this study, the stability of trinitroglycerin (tng) in polyethylene (peg) 400 was investigated according to arrhenius approach. the reaction rate constant (k) for the thermal disintegration of tng in peg 400 at various temperatures was counted based on the percents of remaining tng at different intervals of time at a specific temperature. the results showed that “k” at 40, 50, 60, 70, 80 and...

objective(s):to evaluate the effect of trinitroglycerin (tng) as nitric oxide donor agent on serum copper (cu) and zinc (zn) levels and liver enzymes in balb/c mice infected with leishmania major (l. major) mrho/ir/75/er. materials and methods: inbred female mice were divided into three groups: healthy group (uninfected naive mice), control group (infected with l. major), and test group (l. maj...

BACKGROUND Today, ischemic heart diseases (IHDs) are the most common diseases worldwide. Angiography is the best way to diagnose IHDs. Angiographic complications however can include death, myocardial infarction, nausea, spasm of the coronary arteries, chest pain, bradyarrhythmia, hypotension, or hypertension. This study aimed to determine the effects of a simultaneous injection of trinitroglyce...

     In this study, the stability of trinitroglycerin (TNG) in polyethylene (PEG) 400 was investigated according to Arrhenius approach. The reaction rate constant (k) for the thermal disintegration of TNG in PEG 400 at various temperatures was counted based on the percents of remaining TNG at different intervals of time at a specific temperature. The results showed that “k” at 40, 50, 60, 70, 8...