Background Psychological stress has been implicated in promoting cancer recurrence and progression, but the magnitude of this effect and underlying mechanism remain unclear. In attempt to address this controversy, we have evaluated the impact of stress on molecular and cellular components of cancer Immune-surveillance and tested the hypothesis that the impact of stress in promoting tumorassocia...

249 Received May 7, 2014; revised and accepted July 7, 2014. Published online August 2, 2014; doi: 10.1620/tjem.233.249. Correspondence: Satoru Motoyama, M.D., Ph.D., Department of Surgery and Department of Comprehensive Cancer Control, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, Akita 010-8502, Japan. e-mail: [email protected] C-Reactive Protein Reduces the R...

Material and methods MM pts received an induction therapy with IPI 10 mg/kg every 3 weeks (Q3W) for four doses and FTM 100 mg/m2 weekly for 3 weeks. Peripheral blood lymphocytes (PBMC) and sera were collected at baseline, wk12, and wk24 to perform phenotypic and functional T cell assays, and to investigate humoral responses against a panel of tumorassociated antigens (TAAs) and soluble NKG2D li...

As reported in a recent article in the Journal, Joseph and Isaacs (1) tried to combine Linomide® with other antiangiogenic agents known to inhibit tumorassociated macrophages (TAMs) to evaluate their joint antitumor effects. Unfortunately, the combination of Linomide with other antiangiogenic agents did not result in potentiation of therapeutic efficacy. Instead, one of these agents, pentoxifyl...

With the identification of tumorassociated antigens more than 30 y ago and the development of hybridoma technology in 1975, investigators realized that Paul Ehrlich’s vision to effectively target drugs to diseased tissues could be tested. It was shown that monoclonal antibodies could specifically target tumors (1,2), and it was hypothesized that cancer could be treated with naked antibodies by ...

Antibodies raised in heterologous species against tumorassociated antigens such as ferritin and carcinoembryonic antigen may be utilized in diagnostic scanning and in cancer therapy. The radiolabeled (131I)antibodies have a mean effec tive half-life of 3 days. The tumor-bearing regions retain activity which was associated with objective evidence of remission in primary hepatic cancers. Major or...

Introduction Tumor PD-L1 expression is associated with increased tumor-infiltrating lymphocytes (TILs) in diverse solid tumors, including lung cancer. In addition, PD-L1 upregulation in tumor and/or stromal immune cells has been associated with increased clinical benefit to PD-1/ PD-L1 axis blockers. The significance of PD-L1 expression in different immune cell subpopulations at the tumor micro...

Cellular non-coding RNA (ncRNA) transcription and regulation has only recently been systematically investigated. Studies have demonstrated abundant transcription of a set of ncRNAs preferentially within tumors as opposed to normal tissue. In some cases these tumorassociated ncRNAs also associate with inflammatory cytokine production suggesting potential immunostimulatory qualities. Using a nove...

DKK1 IS A WIDELY EXPRESSED AND POTENT TUMORASSOCIATED ANTIGEN IN MULTIPLE MYELOMA Jianfei Qian, Jin Xie, Sungyoul Hong, Jing Yang, Liang Zhang, Xiaohong Han, Michael Wang, Fenghuang Zhan, John D. Shaughnessy, Jr., Joshua Epstein, Larry W. Kwak, and Qing Yi Department of Lymphoma and Myeloma, Division of Cancer Medicine, and the Center for Cancer Immunology Research, The University of Texas M. D...

Monoclonal antibodies (mAbs) have long been recognized as effective tumor-targeting vehicles. Targeted delivery of radionuclides to tumorassociated antigens for imaging and therapy of cancer is an active research area in the preclinical as well as the clinical domain [2]. The U.S. Food and Drug Administration’s (FDA) approval at the beginning of this century of the first two radiolabeled monocl...