The biodegradation effect and pathway of unsymmetrical dimethylhydrazine (UDMH), which is a major rocket propellant with highly toxic properties, with two strains isolated from the acclimated activated sludge were investigated in solution and in soil. The results demonstrated that Stenotrophomonas sp. M12 (M12) was able to degrade UDMH of 50 mg ̈ L ́1 as the sole carbon source in aqueous mineral ...

Owing to their present use as rocket fuels and their pharmacologic activity as central nervous system stimulants, substituted hydrazines and hydrazine derivatives have come into increasing use in recent years. The parent compound hydrazine and the methyl-substituted hydrazines are of potential hazard because of their toxicity, volatility, and explosive nature. Exposure to hydrazine vapor brings...

Very few animal studies have used 1,1-dimethyl hydrazine (unsymmetrical dimethyl hydrazine - UDMH) as a carcinogen. This study was designed to investigate the carcinogenicity of UDMH in the gastrointestinal tract in a rat model. We wanted to observe if there were any changes in tissue zinc levels and tissue copper zinc superoxide dismutase (CuZnSOD) enzyme activity during the carcinogenic proce...

[methyl-14C]Daminozide (succinic acid 2',2'-dimethylhydrazide; 37 mg/kg), 1,1-[14C]dimethylhydrazine (UDMH; 19 mg/kg), and [14C]dimethylnitrosamine (DMNA; 0.1 mg/kg) were administered by oral gavage to male Sprague-Dawley rats. After 24 hr, the animals were killed and DNA was purified from the livers to constant specific radioactivity. After enzymatic degradation of the DNA to the 3'-deoxynucle...

While researchers have extensively studied the initial decomposition mechanism of Monomethylhydrazine (MMH, CH3NHNH2) in MMH/dinitrogen tetroxide (NTO) system, investigation Unsymmetrical Dimethylhydrazine (UDMH, (CH3)2NNH2) has been limited due to its high toxicity, corrosiveness, and deterioration rate. Hence, effects UDMH’s products on combustion performance gas-phase reaction mechanisms rem...

Within recent years hydrazine and the methyl substituted hydrazines have come into considerable use as rocket fuels. As a result of this increased production of hydrazines, the possibility of accidental human exposure is of considerable interest. Obvious concern results from the fact that hydrazine had been used as an experimental means of producing fatty liver in experimental animals for many ...

The Subacute Toxicity of l,l-Dimethylhydrazine. CORNISH, HERBERT H., and HARTUNG, ROLF (1969). Toxicol. Appl. Pharmacol. 15, 62-68. Daily injections of 70,50,30, or 10 mg UDMH/kg resulted in the death of 9,6, 5, and 0 rats, respectively, in each group of 10. All deaths occurred within the first 3 days. Animals surviving the first 3 days began to gain weight even though daily dosing was continue...

A portable system for the detection of low concentrations of nitrogen tetroxide (N2 0 4 ), fluorine (F 2 ), and unsymmetrical dimethylhydrazine (UDMH) in air has been developed. The detection system is based upon the change of electrical resistivity of thin metal films when exposed to these gases. Silver metal films coated with appropriate salts proved to be applicable to the detection of all t...

Petersen, P., Bredahl, E., Lauritsen, O., and Laursen, T. (1970). Brit. J. industr. Med., 27, 141-146. Examination of the liver in personnel working with liquid rocket propellants. Personnel working with liquid rocket propellants were subjected to routine health examinations, including liver function tests, as the propellant, unsymmetrical dimethylhydrazine (UDMH) is potentially toxic to the li...