The five-subunit WASH complex generates actin networks that participate in endocytic trafficking, migration and invasion in various cell types. Loss of one of the two subunits WASH or strumpellin in mice is lethal, but little is known about their role in mammals in vivo. We explored the role of strumpellin, which has previously been linked to hereditary spastic paraplegia, in the mouse melanocy...

Aim: The objective of the present study is to design and evaluate mucoadhesive microspheres for oral controlled release. Materials and Method: Rosiglitazone maleate microspheres with a coat consisting of alginate and a mucoadhesive polymer sodium carboxymethylcellulose, carbopol 934P and hydroxypropylmethylcellulose were prepared by an orifice-ionic gelation process. The microspheres were evalu...

Metronidazole microcapsules with a coat consisting of alginate and the natural cationic polymer, chitosan were formulated by using tripolyphosphate cross-linking method and were investigated with a view to develop mucoadhesive microcapsules. The microcapsules were evaluated for their surface morphology, microencapsulation efficiency, in-vitro wash-off test, swelling behavior and in-vitro drug r...

This article presents the research results on production and performance of palladium-only catalytic converters. Monolith is used as the catalyst carrier and gamma alumina as the substrate. Dipping method is used for monolith washcoating. Palladium as the active metal is impregnated on gamma alumina using wet impregnation to produce catalyst samples. The effects of factors such as percent solid...

Dermatology. TTVnm an article on the general treatment of skin-diseases, by ??x i?.?{?" appeared in the Deutsche Med. Wochenschrift, No. 19 of 1907, the following notoe are made, as being likely to be of service to many of out readers Regarding the evil effects of washing, with or without the use of soap of the affected part in a case of inflammatory skindisease, such as eczema, we may easily c...

THE problem of perspiration and its removal from the amputee's arm and leg stumps encased in sockets has engaged the attention of the doctor and limb fitter for as long as limbs have been fitted. In the early days of leather prostheses, a few months of wear during the summer were sufficient to cause the leather to rot and degrade because of perspiration. Since it was not possible to wash leathe...

Vesicle biogenesis machinery components such as coat proteins can interact with the actin cytoskeleton for cargo sorting into multiple pathways. It is unknown, however, whether these interactions are a general requirement for the diverse endosome traffic routes. In this study, we identify actin cytoskeleton regulators as previously unrecognized interactors of complexes associated with the Herma...

Isolated human fibroblast plasma membranes that were attached by their extracellular surface to a solid substratum contained numerous clathrin coated pits that could be removed with a high pH buffer (Moore, M.S., D.T. Mahaffey, F.M. Brodsky, and R.G.W. Anderson. 1987. Science [Wash. DC]. 236:558-563). When these membranes were incubated with coat proteins extracted from purified bovine coated v...