نتایج جستجو برای: Weighted gene co-expression network analysis

تعداد نتایج: 4838665  

Fan G Xue Zh

Background: Mammalian preimplantation development is a complex process involving dramatic changes in the transcriptional architecture. However, it is still unclear about the crucial transcriptional network and key hub genes that regulate the proceeding of preimplantation embryos. Materials and Methods: Through single-cell RNAsequencing (RNA-seq) of both human and mouse preimplantation embryos, ...

ژورنال: بیماری های پستان 2021

Introduction: HER2-enriched subtype of breast cancer has a worse prognosis than luminal subtypes. Recently, the discovery of targeted therapies in other groups of breast cancer has increased patient survival. The aim of this study was to identify genes that affect the overall survival of this group of patients based on a systems biology approach. Methods: Gene expression data and clinical infor...

Journal: :molecular biology research communications 0
zahra zinati agroecology department, college of agriculture and natural resources of darab, shiraz university, iran roohollah shamloo-dashtpagerdi crop production and plant breeding department, college of agriculture, shiraz university, iran ali behpouri agroecology department, college of agriculture and natural resources of darab, shiraz university, iran

as an aromatic and colorful plant of substantive taste, saffron (crocus sativus l.) owes such properties of matter to growing class of the secondary metabolites derived from the carotenoids, apocarotenoids. regarding the critical role of micrornas in secondary metabolic synthesis and the limited number of identified mirnas in c. sativus, on the other hand, one may see the point how the characte...

2016
Dong Li James B. Brown Luisa Orsini Zhisong Pan Guyu Hu Shan He

Gene co-expression network differential analysis is designed to help biologists understand gene expression patterns under different conditions. We have implemented an R package called MODA (Module Differential Analysis) for gene co-expression network differential analysis. Based on transcriptomic data, MODA can be used to estimate and construct condition-specific gene co-expression networks, an...

Journal: :Statistical applications in genetics and molecular biology 2005
Bin Zhang Steve Horvath

Gene co-expression networks are increasingly used to explore the system-level functionality of genes. The network construction is conceptually straightforward: nodes represent genes and nodes are connected if the corresponding genes are significantly co-expressed across appropriately chosen tissue samples. In reality, it is tricky to define the connections between the nodes in such networks. An...

Journal: :Genetics 2013
Jesse D Munkvold Debbie Laudencia-Chingcuanco Mark E Sorrells

Quantitative phenotypic traits are influenced by genetic and environmental variables as well as the interaction between the two. Underlying genetic × environment interaction is the influence that the surrounding environment exerts on gene expression. Perturbation of gene expression by environmental factors manifests itself in alterations to gene co-expression networks and ultimately in phenotyp...

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