Five medicinal plants of Pakistan were investigated for their antinociceptive, anti-inflammatory, antidepressant, and anticoagulant potential. Antinociceptive activity was estimated by hot plate and writhing assay. In hot plate assay, Quercus dilatata (52.2%) and Hedera nepalensis (59.1%) showed moderate while Withania coagulans (65.3%) displayed a significant reduction in pain. On the other ha...

The present study was carried out to investigate the changes in oxidative and inflammatory status in streptozotocin-induced diabetic rat's kidneys and serum following treatment with Withania coagulans, a popular herb of ethnomedicinal significance. The key markers of oxidative stress and inflammation such as inflammatory cytokines (IL-1β, IL-6, and TNF-α) and immunoregulatory cytokines (IL-4 an...

Callus induction and withanolides production through cell suspension culture of Withania coagulans (Stocks) Dunal

Use of Withania coagulans as herbal coagulant in the production probiotic cheese containing inulin and evaluation its physicochemical, sensory textural properties

results the i/r group showed a significant increase in pycnotic (dying) neurons and pretreatment with wc at doses of 500 mg/kg and 1000 mg/kg significantly reduced pycnotic and tunel positive neurons, in a dose dependent manner in ischemic brain cortex. conclusions our findings indicated that wc has neuroprotective effects and is able to reduce histopathological alterations and apoptosis in bra...

Withania coagulans (family: Solanaceae, English: Indian Cheese Maker, Hindi: Doda Paneer) fruit is known for its ethanopharmacological significance in health care system of India. Diet rich in high-fat is an important risk factor for diabetes, atherosclerosis and macro and microvascular complications. Treatment with aqueous extract of fruit of W. coagulans (aqWC; 250 mg/kg body weight) in chole...

objective: oxygen free radicals may be implicated in the pathogenesis of ischemia reperfusion damage. the beneficial effects of antioxidant nutrients, as well as complex plant extracts, on cerebral ischemia-reperfusion injuries are well known. this study was conducted to determine the effects of the hydro-alcoholic root extract of withania coagulans on ca1 hippocampus oxidative damages followin...