Xenotransplantation, in its broadest sense, is the transplantation, implantation, or infusion of cells, tissues, organs from one species to another. While there a high demand for human and use clinical they are often short supply. Recent scientific biotechnological advancements, coupled with scarcity allografts, have led renewed interest developing exploratory treatment strategies that xenotran...

Xenotransplantation, the transplantation of living organs, tissues, or cells from one species to another, is viewed as a potential solution to the existing shortage of human organs for transplantation. While whole-organ xenotransplantation is still in the preclinical stage, cellular xenotransplantation and extracorporeal perfusion applications are showing promise in early clinical trials. Advan...

The National Heart, Lung, and Blood Institute (NHLBI) recently convened the Heart and Lung Xenotransplantation Working Group to identify hurdles to the clinical application of xenotransplantation, defined as the use of animal organs or tissue for transplantation, and to recommend possible solutions to these problems. The group consisted of experts in xenotransplantation from academia, industry,...

Xenotransplantation the transplantation of animal cells, tissues or organs into humans to treat diseases, could be an alternative to other methods. Xenotransplantation products could function for prolonged periods when given to recipients who survive for many years. Xenotransplantation is a public health concern because it has the potential to infect human recipients with infectious agents that...

Xenotransplantation marks a qualitatively new challenge in medical technology assessment. The reasons for this claim are twofold: (i) in contrast to more traditional medical interventions, xenotransplantation involves risks not only to the patient, but also to larger segments of society, thus to public health in general. (ii) while most medical technologies demand assessment and risk-management...

Pig-to-human xenotransplantation offers a potential bridge to the growing disparity between patients with end-stage organ failure and graft availability. Early studies attempting to overcome cross-species barriers demonstrated robust humoral immune responses to discordant xenoantigens. Recent advances have led to highly efficient and targeted genomic editing, drastically altering the playing fi...

Xenotransplantation reemerged as a promising alternative to conventional transplantation enlarging the available organ pool. However, success of xenotransplantation depends on design and selection specific genetic modifications development robust assays allowing for precise assessment tissue-specific immune responses. Nevertheless, cell-based are often compromised by low proliferative capacity ...