an adult (two years old) iranian cross-breed ram with alopecia, rough hair coats, thick and wrinkled skin,especially on the face, brisket, scrotum, tail and legs, presented with severe pruritus, poor condition andgeneralized unthriftiness. the animal was referred to the veterinary clinic of shahid bahonar university ofkerman. the vital signs and haematologic indices of the animal were normal. a...

Among the micronutrients required by humans, zinc has particularly divergent modes of action. cDNA microarray and quantitative PCR technologies were used to investigate the zinc responsiveness of known genes that influence zinc homeostasis and to identify, through global screening, genes that may relate to phenotypic outcomes of altered dietary zinc intake. Human monocytic/macrophage THP-1 cell...

Zinc-responsive acral dermatitis is a rare entity characterized by chronic, persistent, well-defined, hyperpigmented, and hyperkeratotic plaques on the regions of body. One needs to differentiate this disease from its close differentials such as necrolytic migratory erythema pellagra. Herein, we report case zinc-responsive dermatosis in 35-year-old female previously treated with multiple topica...

Zinc finger proteins with high affinity for human immunodeficiency virus Rev responsive element stem loop IIB (RRE-IIB) were previously isolated from a phage display zinc finger library. Zinc fingers from one of these proteins, RR1, were expressed individually and assayed for RRE-IIB affinity. The C-terminal zinc finger retained much of the binding affinity of the two-finger parent and was disr...

An adult (two years old) Iranian cross-breed ram with alopecia, rough hair coats, thick and wrinkled skin,especially on the face, brisket, scrotum, tail and legs, presented with severe pruritus, poor condition andgeneralized unthriftiness. The animal was referred to the Veterinary Clinic of Shahid Bahonar University ofKerman. The vital signs and haematologic indices of the animal were normal. A...

Metal-responsive transcription factor 1 (MTF-1) is essential for activating transcription of the metallothionein genes in response to multiple species of heavy metals by binding to the metal-responsive element (MRE) located in the upstream region of the genes. In contrast, MTF-1 binding to the MRE in vitro is induced only by zinc ions, suggesting that MTF-1 acts as a zinc sensor protein. Althou...

The micronutrient zinc has an essential role in physiological and metabolic processes in plants as a cofactor or structural element in 300 catalytic and noncatalytic proteins, but it is very toxic when available in elevated amounts. Plants tightly regulate their internal zinc concentrations in a process called zinc homeostasis. The exceptional zinc hyperaccumulator species Thlaspi caerulescens ...

Zinc transporters are solute carrier family members. To date, 10 zinc transporters (ZnTs) and 14 Zrt-, Irt-like proteins (ZIPs) have been identified. ZnTs control intracellular zinc levels by effluxing zinc from the cytoplasm into the extracellular fluid, intracellular vesicles, and organelles; ZIPs also contribute to control intracellular zinc levels with influxing zinc into the cytoplasm. Rec...

The zinc finger protein, metal response element-binding transcription factor-1 (MTF-1) regulates the expression of genes in response to metal ions and oxidative stress. The precise mechanisms by which this occurs are not understood. To further examine this problem, mouse MTF-1 was expressed in Saccharomyces cerevisiae and tested for the ability to activate metal response element-driven reporter...