BACKGROUND The use of prototypic strains is common among laboratories studying infectious agents as it promotes consistency for data comparability among and between laboratories. Schu S4 is the prototypic virulent strain of Francisella tularensis and has been used extensively as such over the past six decades. Studies have demonstrated virulence differences among the two clinically relevant sub...

The Ca channel b subunit has been shown to reduce the magnitude of G-protein inhibition of Ca channels. However, neither the specificity of this action to different forms of G-protein inhibition nor the mechanism underlying this reduction in response is known. We have reported previously that coexpression of the Ca channel b3 subunit causes M2 muscarinic receptor-mediated inhibition of a1B Ca 2...

Projected changes in emissions and climate will impact future air quality and related human and environmental health. In this work, an advanced online-coupled meteorology and chemistry model, the Weather Research and Forecasting Model with Chemistry (WRF/Chem), has been applied to the continental U.S. for current (2001–2010) and future (2046–2055) decades under four emission/ climate scenarios ...

We have characterized the pharmacological antagonism, i.e., neutral antagonism or inverse agonism, displayed by a number of a-blockers at two a1-adrenergic receptor (AR) subtypes, a1aand a1b-AR. Constitutively activating mutations were introduced into the a1a-AR at the position homologous to A293 of the a1b-AR where activating mutations were previously described. Twenty-four a-blockers differin...

Grassland loss has been extensive worldwide, endangering the associated biodiversity and human well-being that are both dependent on these ecosystems. Ecologists have developed approaches to restore grassland communities and many have been successful, particularly where soils are rich, precipitation is abundant, and seeds of native plant species can be obtained. However, climate change adds a n...

[1] Stratospheric ozone is expected to increase during the 21st century as the abundance of halogenated ozone‐depleting substances decrease to 1960 values. However, climate change will likely alter this “recovery” of stratospheric ozone by changing stratospheric temperatures, circulation, and abundance of reactive chemical species. Here we quantify the contribution of different mechanisms to ch...

Home Blood Pressure Measurement: Ensuring Quality and Interpreting Results Donald W. McKay, Ph.D. Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NL, Canada A1B 3V6 Running Title: Quality Home Blood Pressure Measures

This study is about four cacti species in the state of Chihuahua, (Coryphantha macromeris, Mammillaria lasiacantha, Echinocereus dasyacanthus and Ferocactus wislizenii). Geographic distribution was inferred with MaxEnt. Projection was estimated under three scenarios simulated from IPCC (A2, B1 and A1B) and four periods (2000, 2020, 2050 and 2080) with 19 climatic variables. MaxEnt projects a sp...

Voltage-dependent calcium channels (VDCCs) are heteromultimers composed of a pore-forming a1 subunit and auxiliary subunits, including the intracellular b subunit, which has a strong influence on the channel properties. Voltage-dependent inhibitory modulation of neuronal VDCCs occurs primarily by activation of G-proteins and elevation of the free Gbg dimer concentration. Here we have examined t...