نتایج جستجو برای: abca1
تعداد نتایج: 1947 فیلتر نتایج به سال:
Rationale: Macrophages cannot limit the uptake of lipids and rely on cholesterol efflux mechanisms for maintaining cellular cholesterol homeostasis. Important mediators of macrophage cholesterol efflux are ATP-binding cassette transporter 1 (ABCA1), which mediates the efflux of cholesterol to lipid-poor apolipoprotein AI, and scavenger receptor class B type I (SR-BI), which promotes efflux to m...
بیماری کرونری قلبی یکی از مهمترین علل مرگ و میر در بیشتر کشورهاست. این بیماری با افزایش مقدار لیپوپروتئین کمچگال (LDL-C) پلاسما رابطة مستقیم و با لیپوپروتئین پرچگال (HDL-C) رابطة معکوس دارد. ABCA1 خارجکنندة اصلی کلسترول و فسفولیپید از سلول به آپولیپوپروتئین عاری از لیپید یا دارای حداقل لیپید است. نتایج تحقیقات بهروشنی نشان میدهد که عملکرد ABCA1 نقش کلیدی در فرایند انتقال معکوس کلسترول و...
مقدمه: فرایند انتقال معکوس کلسترول شامل جمعآوری کلسترول اضافی از بافتهای پیرامونی و بازگرداندن آن به کبد به منظور تشکیل صفرا است. این فرایند شامل خروج کلسترول و فسفولیپید از سلول توسط ناقل جعبهای وابسته به آدنوزین تریفسفات (ABCA1) به آپولیپوپروتئینهای A-I برای تشکیل لیپوپروتئینهای پرچگال پریبتای صفحهای و در نهایت استریفه شدن کلسترول توسط آنزیم پلاسمایی لسیتینکلسترولآسیلترانسفراز برای...
Background & Aims: ABCA1 as a member of the ABC transporters family plays a crucial role in RCT, HDL-C formation andultimatly CAD prevention. The purpose of this study was to investigate ABCA1 expression in lymphocytes, plasma apolipoprotein A-I and lipid profiles in response to eight weeks interval combined endurance training (ICET) among overweight and obese boy adolescents. Materials & Meth...
The ATP-binding cassette transporter A1 (ABCA1) mediates the cellular efflux of excess cholesterol and phospholipids to lipid-poor apolipoprotein A-I (apoA-I). ABCA1 plays an important role in high-density lipoprotein (HDL) biogenesis and reverse cholesterol transport. By using a cell-based screening model for the ABCA1 up-regulator and column chromatography, an active compound, 9179B, was isol...
PURPOSE OF REVIEW The appearance of scavenger receptor class B type I (SR-BI) and ATP-binding cassette transporter A1 (ABCA1) in macrophages and liver implicates these transporters in different stages of reverse cholesterol transport. This review focuses on the role of SR-BI and ABCA1 in reverse cholesterol transport in the context of atherosclerotic lesion development. RECENT FINDINGS Recent...
ABCA1, ABCA7, and ABCA4 are members of the ABCA subfamily of ATP-binding cassette transporters that share extensive sequence and structural similarity. Mutations in ABCA1 cause Tangier disease characterized by defective cholesterol homeostasis and high density lipoprotein (HDL) deficiency. Mutations in ABCA4 are responsible for Stargardt disease, a degenerative disorder associated with severe l...
Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules
OBJECTIVE The ATP-binding cassette transporter A1 (ABCA1) is essential for normal insulin secretion from β-cells. The aim of this study was to elucidate the mechanisms underlying the impaired insulin secretion in islets lacking β-cell ABCA1. RESEARCH DESIGN AND METHODS Calcium imaging, patch clamp, and membrane capacitance were used to assess the effect of ABCA1 deficiency on calcium flux, io...
Sterol efflux importantly contributes to preservation of cellular cholesterol homeostasis, and multiple pathways may be involved for mediating such efflux. Recently, an important role has been ascribed to ABCA1 in facilitating lipid efflux from cells, including macrophages, to extracellular lipid-free apolipoproteins. Macrophages are relatively unique among cells because they express apoprotein...
Cerebral amyloid-β (Aβ) deposition is a critical feature of Alzheimer's disease. Aβ is derived from the amyloid-β protein precursor (AβPP) via two sequential cleavages that are mediated by β-secretase and the γ-secretase complex. Such amyloidogenic AβPP processing occurs in lipid raft microdomains of cell membranes and it is thought that modulating the distribution of lipids in rafts may regula...
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