Introduction The antigens of the ABO blood group system (A, B and H determinants, respectively) are complex carbohydrate molecules on the extracellular surface of red blood cells1. However, besides being expressed on red blood cells, ABO antigens are also strongly expressed on the surface of a variety of human cells and tissues, including the epithelium, sensory neurones, platelets, and the vas...

Antigens of the ABO blood group system (i.e., A, B, and H antigens) and Rhesus factor were discovered more than one century ago by karl & steiner [1,2] who is considering the father of transfusion medicine, and with this discovery he enabling physicians to transfuse blood without endangering the patient′s life. The ABO antigens are defined by carbohydrate moieties on the extracellular surface o...

Hemolytic disease of newborn (HDN) is caused by the emergence of inappropriate antibodies against fetal blood antigens, which includes ABO and Rh blood group incompatibility. This study investigated the association between prenatal blood group antibody titer and HDN to provide a theoretic basis for clinical practice. ABO and Rh blood group of 7894 pregnant women and their husbands were screened...

Association between certain systemic diseases and ABO blood group is a well known fact. The purpose of this study was to determine whether there is any association between periodontal disease and ABO blood groups. A cross sectional study was carried-out on 200 subjects who were randomly selected from individuals referred for periodontal treatment. The study subjects were segregated into healthy...

Since the first link between blood type and cancer was described in 1953, numerous studies have sought to determine whether the histoblood ABO group is associated with tumorigenesis. In 2009, the first significant association between a SNP located within the ABO glycosyltransferase gene and increased risk of pancreatic cancer was reported. Here, we describe the history and possible functions of...

SUMMARY: BACKGROUND: The gene locus for the ABO blood group system encodes a glycosyltransferase. Alterations in the DNA sequence are associated with the blood groups and the expression levels of antigens on red blood cells. A number of ABO alleles have been described as the molecular basis of weak A or B antigens. PATIENTS AND METHODS: Here, we describe a novel variant B allele in a blood dono...