Pemphigus vulgaris (PV) is an autoimmune blistering disorder of the skin and mucosal surfaces characterized by acantholysis (loss adhesion between epidermal cells). Esophageal involvement PV underdiagnosed entity as routine diagnostic endoscopy not recommended in asymptomatic patients. Dysphagia odynophagia are common presenting symptoms; however, upper gastrointestinal bleeding (UGIB) associat...

Abstract Background A hypertrophic / vegetating variant of Darier disease causing massive verruciform genital tumors is exceedingly rare. Case presentation woman in her late 50s underwent wide resection vulva and inguinal skin due to lesion. She had crusted keratotic plaques with appearance follicular keratosis (with a greasy, warty texture) the back, neck, face, extremities for 27 years. Previ...

We describe the case of a 67-year-old woman affected by pemphigus vulgaris with a dry whitish scaly lesion in the upper lip. Clinically, this lesion resembled an actinic keratosis. Although histological examination revealed a focal acantholysis, the finding of a moderate-to-severe dysplastic epithelium was consistent with the diagnosis of acantholytic actinic keratosis with moderate/severe dysp...

Apoptosis plays a role in pemphigus IgG-dependent acantholysis; theoretically, the blockade of the caspase pathway could prevent the blistering that is caused by pemphigus autoantibodies. Using this strategy, we attempted to block the pathogenic effect of pemphigus IgG in Balb/c mice by using the caspase inhibitor Ac-DEVD-CMK. This inhibitor was administrated before the injection of pemphigus I...