Oral immunotherapy (OIT) is a promising therapeutic approach for treating food allergy. Past studies have shown that OIT reduces allergic response only in severe allergy model mice. We worked to establish mild allergy model mice, and investigated whether 'rush' OIT for 10 d improved the allergic response and biomarkers in these mice. Balb/c mice were sensitized to ovomucoid (OM) in alum. The ru...

OBJECTIVES We performed a prospective study to analyze mast cell mediators as predictors of systemic adverse reactions during rush venom-specific immunotherapy (VIT) in children. PATIENTS AND METHODS Nineteen children aged 5-17 years received VIT with Venomenhal (HALAllergy). We analyzed serum tryptase (CAP, Phadia), plasma prostaglandin (PG) D2 metabolites (9alpha, 11beta-PGF2), and urine PG...

BACKGROUND Food allergy (FA) negatively affects quality of life in caregivers of food-allergic children, imposing a psychosocial and economic burden. Oral immunotherapy (OIT) is a promising investigational therapy for FA. However, OIT can be a source of anxiety as it carries risk for allergic reactions. The effect of OIT with multiple food allergens (mOIT) on FA-specific health-related quality ...

License to glue eplication of DNA and cohesion of the resultant sister chromatids are two activities that must be coordinated. found that the same " licensing " process that gets DNA ready for replication is also necessary to allow loading of the cohesin complex responsible for sister chromatid cohesion. Gillespie and Hirano used the sequence of yeast cohesin-loading proteins to identify human ...

2289. A Multicenter Study of the Clinical and Molecular Epidemiology of TEMand SHV-type ExtendedSpectrum β-Lactamase producing (ESBL) Enterobacteriaceae (Ent) Infections in Children Jared R. Rispens, MD; Rachel L. Medernach, MD; Andrea M. Hujer, BS; T. Nicholas Domitrovic, BA; Steven H. Marshall, MS; Susan D. Rudin, BS; Xiaotian Zheng, MD, PhD; Nadia K. Qureshi, MD; Mary K. Hayden, MD, FIDSA, F...

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Jennifer Vines This is the fi rst of 12 Correspondence pieces in this issue that are in response to an important PLoS Medicine Research Article: Auvert B, Taljaard D, Lagarde E, Sobngwi-Tambekou J, Sitta R, et al. (2005) Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: The ANRS 1265 trial. PLoS Med 2(11): e298. Readers wishing to add their own ...