Acetaminophen induces the mitochondrial permeability transition (MPT) in hepatocytes. Reactive oxygen species (ROS) trigger the MPT and play an important role in AAP-induced hepatocellular injury. Because iron is a catalyst for ROS formation, our aim was to investigate the role of chelatable iron in MPT-dependent acetaminophen toxicity to mouse hepatocytes. Hepatocytes were isolated from fasted...

Acetaminophen, a pain-reliever, is one of the most widely used medications in the world. Acetaminophen with normal dosage is considered a nontoxic drug for therapeutic applications, but when taken at overdose levels it produces liver damage in human and various animal species. By a high energy mechanically activated method, we produced acetaminophen in a nanometer crystalline size (24 nm). Fort...

Metabolomics approaches have enabled the study of new mechanisms of liver injury in experimental models of drug toxicity. Disruption of bile acid homeostasis is a known mechanism of drug induced liver injury. The relationship of individual bile acids to indicators of oxidative drug metabolism (acetaminophen protein adducts) and liver injury was examined in children with acetaminophen overdose, ...

Individuals with lymphatic filariasis (LF) shows elevated levels of pro-inflammatory cytokines, altered expressions of inflammatory genes and are prone to secondary bacterial infection. Also markers of liver dysfunction were reported to be high with increased filarial infection. Acetaminophen (Paracetamol), an anti-pyretic drug was prescribed to LF individuals along with Diethylcarbamazine and ...

Acetaminophen is a popular over-the-counter analgesic used for headaches and minor musculoskeletal pains. Most persons taking therapeutic doses of acetaminophen experience no side effects. \¥hen taken in greater than the recommended dosage, however, acetaminophen can cause serious complications, including liver and renal failure as well as death. l This outcome is especially evident in those wh...

Acetaminophen (APAP) overdose causes liver injury, but in some cases it is associated also with renal impairment. While several studies exist in relation to acetaminophen nephrotoxicity, no reports have been published describing intracellular changes related to APAP nephrotoxicity in vitro. Because proximal tubular cells are considered to constitute a secondary site of drug-induced injury after...

INTRODUCTION Acetaminophen toxicity, which can lead to hepatotoxicity, is a burden on our health care system and contributes significantly to intensive care unit admissions and cost of hospitalization. The aim of our study was to determine the epidemiology of various types of acetaminophen poisoning and analyze their outcome compared with their admission characteristics. METHODS We identified...