BACKGROUND Findings from both epidemiological and basic research point to the possibility that NSAIDS impede the deterioration in schizophrenia. METHODS To study the efficacy of acetylsalicylic acid we will perform a randomized placebo controlled double-blind add-on trial of 80 inpatients and outpatients with schizophrenia, schizophreniform or schizoaffective disorder. Patients will be 1:1 ra...

Introduction: Hyperaggregation of platelets can cause the formation of thrombi and subsequent occlusion of blood vessels leading to ischemia. This phenomenon can be responsible for ischemic cardiovascular diseases such as angina pectoris, atherosclerosis, stroke and other forms of ischemia. To decrease platelet function and reduce the formation of thrombi, acetylsalicylic acid has been used for...

Acute salicylate overdose in pregnancy is potentially fatal for both the mother and fetus and presents a unique challenge in intensive care management. While suggested thresholds exist for hemodialysis in adults with toxic salicylate ingestion, it is unclear if these thresholds remain appropriate for the gravid patient, particularly given that medications such as acetylsalicylic acid may cross ...

Numerous studies have shown the preventive effect of the use of dual antiplatelet therapy using acetylsalicylic acid and clopidogrel in reducing the risk of cardiovascular events in patients after acute coronary syndrome (ACS) and those undergoing percutaneous coronary intervention (PCI). Consequently every clinical guideline has incorporated the use of dual antiplatelet therapy for ACS and PCI...

Acetylsalicylic acid (aspirin) is a common nonsteroidal anti-inflammatory drug used for treatment of pain and arthritis. In the body, acetylsalicylic acid is rapidly deacetylated to form salicylic acid. Both compounds have been proposed as anti-inflammatory agents. Major metabolites of salicylic acid are its acyl and phenolic glucuronide conjugates. Formation of these conjugates, catalyzed by U...

Rectus sheath hematoma is an uncommon and frequently misdiagnosed cause of acute abdominal pain3. Although the exact incidence is unknown, Klingler et al.6 observed 23 cases (1.8%) of rectus sheath hematoma among 1257 patients evaluated by ultrasound for acute abdominal disorders. It is defined as spontaneous in patients without history of abdominal trauma. In these cases, anticoagulation thera...

Some late complications of diabetes are associated with alterations in the structure and function of proteins due to glycation and free radicals generation. Aspirin inhibits protein glycation by acetylation of free amino groups. In the diabetic status, it was demonstrated that several enzymes of heme pathway were diminished. The aim of this work has been to investigate the in vivo effect of sho...

Polymorphonuclear leukocytes (PMNL) concentrate, transport, and release certain antimicrobial agents as they move in a chemotactic gradient. Antipyretic agents are frequently used in febrile patients receiving antimicrobial agents. Thus, the influence of ibuprofen, acetaminophen, and acetylsalicylic acid on uptake, transport, and release of azithromycin and moxifloxacin was studied. Uptake of t...

the selected parts of four medicinal plants, achillea millefolium, hibiscus rosasinensis, linum usitatissimum and pluchea lanceolata were extracted in absolute methanol to determine their analgesic activity. analgesic activity was assessed on intact mice by tail flick latency via the tail immersion method. the analgesic activities of these plant extracts were compared with acetylsalicylic acid ...