Antiplatelet agents, which have been reviewed recently in the vista Española de Cardiologı́a, and acetylsalicylic acid in particular, e essential for the treatment of ischemic heart disease, especially the secondary prevention setting. Hypersensitivity reactions acetylsalicylic acid, whether allergic (IgE-mediated) or eudoallergic (caused by a nonimmunologic mechanism) should t be considered as ...

A-10-year-old girl was referred to our department for multiple hyperpigmented plaques. One week previously, she had been given one suppository of acetylsalicylic acid - phenobarbital for fever. Twelve hours after the drug intake the child developed pruritic red plaques on the left thigh. Six weeks after resolution of the acute reaction, patch tests were performed separately, with phenobarbital ...

Acute intoxication with acetylsalicylic acid is a severe event commonly seen in children resulting from wide availability of this drug without prescription. Cases of self-poisoning resulting from overdose continue to occur and, although far less common, they are often severe and life-threatening. We report a 14-year-old girl who presented to the emergency department with tachypnea and altered m...

The nut of Cola nitida Vent was extracted and examined for its starch constituent and physicochemical properties. The starch was isolated using 1%w/v sodium metabisulphite solution. The starch obtained had a fine texture, white, tasteless and odourless with a pH of 5.5 and moisture content of 9.67%. 75 mg acetylsalicylic acid tablet was formulated with novel starch using direct compression meth...

This study of analgesic hepatotoxicity was conducted on rabbit divided into four equal groups (A—D). The group “A” served as control. The group “B” animals were administered acetylsalicylic acid (600 mg/Kg/day) orally,while group “C” animals received paracetamol (300 mg/Kg/day). The group “D” was given both the acetylsalicylic acid (300 mg/Kg/day) and paracetamol (150 mg/Kg/day). An autopsy was...

Male A/J strain mice were fed AIN-76A diet supplemented with myo-inositol/dexamethasone (10 g and 0.5 mg/kg diet) or acetylsalicylic acid (300 mg/kg) and exposed for 5 months to a mixture of sidestream and mainstream cigarette smoke at a concentration of 132 mg total suspended particulates/m3. After tobacco smoke exposure, they were allowed to recover for another 4 months in filtered air. In th...