The aim of this study was to investigate the adaptation of the cyanobacterium Fischerella sp. ISC 107to combined effects of carbon dioxide concentration, acidic and alkalinity. Axenic strain was incubated in BG0-11 medium. Carbon dioxide treatments were limited and relatively non-limited. Acidic (pH 5), neutral (pH7), and alkaline (pH 9) conditions were employed in each treatment. Survival, gro...

PrPC conversion to PrPSc isoform is the main known cause for prion diseases including Crutzfeldt-Jakob, Gerstmann-Sträussler-Sheinker syndrome and fatal familial insomnia in human. The precise mechanism underling this conversion is yet to be well understood. In the present work,  using the coordinate file of PrPC (available on the Protein Data Bank) as a starting structure, separate molecular d...

BACKGROUND Local acidosis has been demonstrated in ischemic tissues and at inflammatory sites. RESULTS Acidic extracellular pH triggers NLRP3 inflammasome activation and interleukin-1β secretion in human macrophages. CONCLUSION Acidic pH represents a novel danger signal alerting the innate immunity. SIGNIFICANCE Local acidosis may promote inflammation at ischemic and inflammatory sites. L...

The time course of chorionic gonadotropin stimulation of nuclear basic and acidic protein biosynthesis, phosphorylation, and acetylation as well as DNA biosynthesis in ovaries of immature rats has been investigated. After injection of radioactive precursor and chorionic gonadotropin into immature rats, ovarian histone fractions Fl, FZal, F2a2, F2b, and F3 were isolated by selective acid extract...

OBJECTIVE In the deep microenvironments of advanced human atherosclerotic lesions, the intimal fluid becomes acidic. We examined the effect of an acidic extracellular pH on cholesterol removal (efflux) from primary human macrophages. METHODS AND RESULTS When cholesterol efflux from acetyl-low-density lipoprotein-loaded macrophages to various cholesterol acceptors was evaluated at pH 7.5, 6.5,...

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The composition of the major acidic extracellular polysaccharide (EPS) of 25 strains of Rhizobium japonicum was determined. Eight strains synthesized an acidic EPS containing rhamnose and 4-O- methylglucuronic acid and were closely related according to DNA homology. These same strains also expressed high levels of ex planta nitrogenase activity. Sixteen strains produced an acidic EPS containing...

The filamentous fungus, Lambertella corni-maris (L. corni-maris), a mycoparasite on Monilinia fructigena, produces the antibiotics, lambertellols A (1), B (2), and lambertellin (3), in a substantial amounts under acidic conditions, whereas these antibiotics were hardly detected when the fungus was cultured on a potato-sucrose (PS) medium without added acids. Our investigations also revealed tha...