The genus Acinetobacter comprises 47 characterised genomic species, among which species belonging to the Acinetobacter calcoaceticus–Acinetobacter baumannii complex are the most clinically relevant. Within this complex, A. baumannii, Acinetobacter nosocomialis (formerly genomic species 13TU) and Acinetobacter pittii (formerly genomic species 3) are frequently associated with hospital-acquired i...

Polyphosphate (polyP) is a ubiquitous biopolymer whose function and metabolism are incompletely understood. The polyphosphate kinase (PPK) of Acinetobacter sp. strain ADP1, an organism that accumulates large amounts of polyP, was purified to homogeneity and characterized. This enzyme, which adds the terminal phosphate from ATP to a growing chain of polyP, is a 79-kDa monomer. PPK is sensitive t...

Emerging antibiotic resistance has created a major public health dilemma, compounded by a dearth of new antibiotic options. Multidrug-resistant Gram-negative organisms have received less attention than Gram-positive threats, such as methicillin-resistant Staphylococcus aureus, but are just as menacing. Pathogens such as Pseudomonas aeruginosa and Acinetobacter baumannii employ a variety of resi...

The introduction of the fluoroquinolones (FQs) in the 1980s provided clinicians with a class of broad-spectrum agents applicable to a range of gram-negative infections including urinary tract infections, gastrointestinal infections, respiratory tract infections, sexually transmitted diseases, bone and joint infections, and infections of the skin and soft tissue (reviewed in references 10 and 43...

I study a class of lattice versions of QED with fermions with the aim of clarifying the relationship between the fermion spectrum (doubled or not), continuous chiral symmetry, the range of the lattice interactions, and the validity of perturbation theory. Theories of this class with an undoubled spectrum, such as the SLAC formulation, have infiniterange interactions and infrared-divergent pertu...

This report describes the whole-genome shotgun sequences of two multidrug-resistant Acinetobacter baumannii strains, ABE8_07 and ABE12_M, isolated from a Moroccan hospital floor. These two genome sequences will initiate the study and characterization of the Acinetobacter baumannii genome in Morocco.

Here, we report the isolation of 31 Acinetobacter baumannii strains producing OXA-253 in a single large Brazilian city. These strains belonged to five different sequence types (STs), including 4 STs not previously associated with blaOXA-253 In all strains, the blaOXA-253 gene was located in a plasmid within a genetic environment similar to what was found previously in Brazil and Italy. The repo...

Abstract Acinetobacter baumanniiis a growing public health threat due to increasing incidence of carbapenem-resistant strains in U.S. hospitals. With widespread antibiotic resistance, there is an urgent need for alternative therapies treat these infections, which are often acquired hospital intensive care units. Antibody-based immunotherapies offer one potential treatment avenue, however, adapt...