Most of the phospholipid biosynthetic genes of Saccharomyces cerevisiae are coordinately regulated in response to inositol and choline. Inositol affects the intracellular levels of phosphatidic acid (PA). Opi1p is a repressor of the phospholipid biosynthetic genes and specifically binds PA in the endoplasmic reticulum. In the presence of inositol, PA levels decrease, releasing Opi1p into the nu...

INTRODUCTION Language interpretation services for patients who are not proficient in a country's official language(s) are essential for improving health equity across diverse populations, and achieving clinical safety and quality for both patients and providers. Nevertheless, overall use of these services remains low, regardless of how they are delivered. In Toronto, Ontario, one of the most et...

Objective: To study the antioxidant status and the extent of oxidative stress in patients with organophosphorus insecticide (OPI) poisoning before and after specific treatment. Material and Methods: The study was conducted in eighty-four OPI poisoned patients. Superoxide dismutase (SOD) and malonyl aldehyde (MDA) levels were estimated as an index of antioxidant status and oxidative stress respe...

BACKGROUND To validate the association between accommodation and visual asthenopia by measuring objective accommodative amplitude with the Optical Quality Analysis System (OQAS®, Visiometrics, Terrassa, Spain), and to investigate associations among accommodation, ocular surface instability, and visual asthenopia while viewing 3D displays. METHODS Fifteen normal adults without any ocular disea...

Topical protoporphyrin (PpIX)-induced photodynamic therapy (PDT) relies on the penetration of the prodrug into the skin lesion and subsequent accumulation of the photosensitizer. Methyl aminolevulinate (MAL)-PDT is an established treatment for thinner and superficial non-melanoma skin cancers (NMSCs) but for the treatment of the thicker nodular basal cell carcinoma (nBCC) enhanced penetration o...

INTRODUCTION The emergency telephone number 9-1-1 serves as a lifeline to the public during emergencies, and first responders rely on information gathered by 9-1-1 telecommunicators who speak with callers. Timely, accurate information from the telecommunicators is essential for providing appropriate care on scene. Language barriers can hamper these efforts and result in less efficient informati...

PURPOSE To measure and investigate visual functioning and health-related quality of life (QOL) in patients after ocular penetrating injuries (OPI). METHODS Fifty-four adult patients with OPI and 26 healthy control subjects were enrolled in the study. The National Eye Institute Visual Functioning Questionnaire (NEI VFQ-25) and the 36-Item Short Form Health Survey (SF 36) were administered. Soc...

The synthesis, uptake, and processing of yolk proteins remain poorly described aspects of oviparous reproductive development. In this study, we report the identification and characterization of two protease inhibitors in rainbow trout ovary whose expression and distribution are directly associated with yolk protein uptake in vitellogenic oocytes. The first transcript, termed "oocyte protease in...

The SPIRAL2 linear accelerator [1] will produce entirely new particle beams enabling exploration of the boundaries of matter. Coupled with the existing GANIL machine this new facility will produce light and heavy exotic nuclei at extremely high intensities. The field deployment of the Control System relies on Linux PCs and servers, VME VxWorks crates and Siemens PLCs; equipment will be addresse...

A finite element method (FEM) based numerical model of upper airway structures (jaw, tongue, maxilla, soft palate) was implemented to observe interactions between the soft palate and tongue, and in particular to distinguish the contributions of individual muscles in producing speech-relevant constrictions of the oropharyngeal isthmus (OPI), or "uvular" region of the oral tract. Simulations reve...