The purpose of the meeting was to discuss existing and planned measurements of network and HOST behavior. It was agreed (after a ridiculously long discussion) to allocate links 159-191 for network measurement only (see RFC #317). It was further agreed that these links would be allocated in the following way: 159-174 HOST DISCARD; cooperating HOSTS receiving messages on these links will throw th...

In an effort to facilitate public involvement, the staff previously solicited public input during the 2011 NRC Regulatory Information Conference (RIC), held in Rockville, MD. During the RIC, GSI–191 was the subject of one of the RIC technical sessions. Information concerning the 2011 RIC is available at http://www.nrc.gov/public-involve/ conference-symposia/ric. The GSI–191 technical session ag...

Themolecular mechanisms of hypoxia induced breast cell migration remain incompletely understood. Our results show that hypoxia through hypoxia-inducible factor (HIF) brings about a time-dependent increase in the level of an oncogenicmicroRNA,miR-191 in various breast cancer cell lines.miR-191 enhances breast cancer aggressiveness by promoting cell proliferation, migration and survival under hyp...

The molecular mechanisms of hypoxia induced breast cell migration remain incompletely understood. Our results show that hypoxia through hypoxia-inducible factor (HIF) brings about a time-dependent increase in the level of an oncogenic microRNA, miR-191 in various breast cancer cell lines. miR-191 enhances breast cancer aggressiveness by promoting cell proliferation, migration and survival under...

Schizosaccharomyces pombe divides by medial fission through the use of an actomyosin-based contractile ring. A division septum is formed centripetally, concomitant with ring constriction. Although several genes essential for cytokinesis have been described previously, enzymes that participate in the assembly of the division septum have not been identified. Here we describe a temperature-sensiti...

In an effort to produce small discrete fragments of human growth hormone (GH), we examine the action of the proteolytic enzyme, bromelain, on this molecule. Purified human GH incubated for 40 min at 220C with crude bromelain and gel-filtered on Sephadex G-100 resulted in a major digestion product, peak 2. SDS-urea gel electrophoresis in the presence of fl-mercaptoethanol suggested that peak 2 w...

Proteases act in important homeostatic pathways and are tightly regulated. Here, we report an unusual structural mechanism of regulation observed by the 2.5-A X-ray crystal structure of the serine protease, granzyme C. Although the active-site triad residues adopt canonical conformations, the oxyanion hole is improperly formed, and access to the primary specificity (S1) pocket is blocked throug...

Desendan nekrotizan mediastinit boyundan başlayıp mediastene yayılan nadir ve ölümcül bir mediasten infeksiyonudur. Hastanın kurtarılmasını sağlayan anahtar noktalar erken tanı, agresif drenaj ve komplikasyonların dikkatli bir şekilde tedavisidir. Odontojenik kökenli, hemorajik komplikasyon gelişen ve başarılı bir şekilde tedavi edilen desendan nekrotizan mediastinit olgusunu sunuyoruz. Anahtar...