A three-dimensional quantitative structure activity relationship (3D-QSAR) study using comparative molecular field analysis (CoMFA) method was performed on 2,5-disubstituted1,3,4-thiadiazole derivatives as diuretic agents. This study was performed using 40 compounds, in which the CoMFA model was developed using a training set of 30 compounds. Ten compounds (selected at randomly served as a test...

Comparative molecular field analysis (CoMFA) which is a three-dimensional quantitative structure activity relationship (3D-QSAR) technique was performed on 1,3,4-thiadiazole derivatives having anti-inflammatory activity. This study was performed using 28 compounds, in which the CoMFA model was developed using a training set of 25 compounds. Three compounds (selected at randomly served as a test...

eccentric connectivity index has been found to have a low degeneracy and hence a significantpotential of predicting biological activity of certain classes of chemical compounds. wepresent here explicit formulas for eccentric connectivity index of various families of graphs.we also show that the eccentric connectivity index grows at most polynomially with thenumber of vertices and determine the ...

Flexibility is an indispensable component of the ability to carry out activities of daily living. The flexibility test proposed by the American Alliance for Health, Physical Education, Recreation and Dance (AAHPERD) is easy to administer and requires little equipment. Thus, the present study sought to ascertain the validity of the flexibility component of the AAHPERD Functional Fitness Assessme...

Caspase-3 inhibitory activities of some 1, 2-benzisothiazol-3-one derivatives were modeled by quantitative structure-activity relationship (QSAR) using stepwise-multiple linear regression (SW-MLR) method. The built model was robust and predictive with correlation coefficient (R(2)) of 0.91 and 0.59 for training and test groups, respectively. The quality of the model was evaluated by leave-one o...

Neurons integrate inputs from thousands of afferents. Similarly, some experimental techniques record the pooled activity of large populations of cells. When cells in these populations are correlated, the correlation coefficient between the collective activity of two subpopulations is typically much larger than the correlation coefficient between individual cells: The act of pooling individual c...