نتایج جستجو برای: acute kidney injury adipose tissue ischemia

تعداد نتایج: 1734170  

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2012
Katy Sánchez-Pozos Jonatan Barrera-Chimal Juan Garzón-Muvdi Rosalba Pérez-Villalva Roxana Rodríguez-Romo Cristino Cruz Gerardo Gamba Norma A Bobadilla

BACKGROUND Prophylactic mineralocorticoid receptor (MR) antagonism with spironolactone (Sp) in rats completely prevents renal damage induced by ischemia. Because acute renal ischemia cannot typically be predicted, this study was designed to investigate whether Sp could prevent renal injury after an ischemic/reperfusion insult. METHODS Six groups of male Wistar rats were studied: rats that rec...

2017
Christoph Reichetzeder Berthold Hocher

With great interest we have read the publication “Dipeptidyl peptidase 4 inhibitor use is associated with a lower risk of incident acute kidney injury in patients with diabetes” by Chao et al., demonstrating for the first time in a large scale prospectively designed cohort study that the use of DPP-4 inhibitors is associated with a significant risk reduction for the development of acute kidney ...

Journal: :American journal of physiology. Renal physiology 2012
Shenyang Li Kiran Nagothu Gouri Ranganathan Syed M Ali Brian Shank Neriman Gokden Srinivas Ayyadevara Judit Megyesi Gunilla Olivecrona Sumant S Chugh Sander Kersten Didier Portilla

Peroxisome proliferator-activated receptor-α (PPARα) activation attenuates cisplatin (CP)-mediated acute kidney injury by increasing fatty acid oxidation, but mechanisms leading to reduced renal triglyceride (TG) accumulation could also contribute. Here, we investigated the effects of PPARα and CP on expression and enzyme activity of kidney lipoprotein lipase (LPL) as well as on expression of a...

2017
Aleksandra Kezić Natasa Stajic Friedrich Thaiss

Acute kidney injury caused by ischemia and subsequent reperfusion is associated with a high rate of mortality and morbidity. Ischemia/reperfusion injury in kidney transplantation causes delayed graft function and is associated with more frequent episodes of acute rejection and progression to chronic allograft nephropathy. Alloantigen-independent inflammation is an important process, participati...

2011
Almut Grenz Julee H. Hong Alexander Badulak Douglas Ridyard Timothy Luebbert Jae-Hwan Kim Holger K. Eltzschig

In hospitalized patients, over 50% of cases of acute kidney injury (AKI) are caused by renal ischemia. A recent study of hospitalized patients revealed that only a mild increase in serum creatinine levels (0.3 to 0.4 mg/dl) is associated with a 70% greater risk of death than in persons without any increase. Along these lines, surgical procedures requiring cross-clamping of the aorta and renal v...

Journal: :Harran Üniversitesi týp fakültesi dergisi 2021

Background: The aim was to investigate the antioxidant effects of lycopene and caffeine in rats exposed renal ischemia/reperfusion injury. Materials Methods: Following right nephrectomy, 60 minutes ischemia followed by reperfusion were performed 200-250 gram Wistar albino used study. 30 before ischemia, (5 mg/kg), (50 mg/kg) + administered intraperitoneally rats. After experiment, 4 ml blood le...

Journal: :Molecular medicine 2008
Matthieu Legrand Egbert G Mik Tanja Johannes Didier Payen Can Ince

Ischemia is the most common cause of acute renal failure. Ischemic-induced renal tissue hypoxia is thought to be a major component in the development of acute renal failure in promoting the initial tubular damage. Renal oxygenation originates from a balance between oxygen supply and consumption. Recent investigations have provided new insights into alterations in oxygenation pathways in the isc...

2008
Lisa M. Curtis Sifeng Chen Bo Chen Anupam Agarwal Christopher A. Klug Paul W. Sanders

Curtis LM, Chen S, Chen B, Agarwal A, Klug CA, Sanders PW. Contribution of intrarenal cells to cellular repair after acute kidney injury: subcapsular implantation technique. Am J Physiol Renal Physiol 295: F310–F314, 2008. First published April 30, 2008; doi:10.1152/ajprenal.90205.2008.—The kidney is capable of regeneration following injury, particularly following acute insults. Although the me...

Journal: :acta medica iranica 0
kobra farahani department of basic sciences, east tehran branch, islamic azad university, tehran, iran. mehrdad hashemi department of genetics, tehran medical sciences branch, islamic azad university, tehran, iran.

ischemia-reperfusion injury is the tissue damage happened when blood supply returns to the tissue after a period of ischemia or shortage of oxygen. this brain injury initiates an inflammatory response involving the expression of adhesion molecules and cytokines. the aim of this study is investigating the effect of hydroalcoholic extract of  cyperus rotundus l. on the expression of the bcl-x1 an...

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