introduction: acute kidney injury (aki) is a common postoperative complication of cardiac surgery, which is associated with an increased risk of morbidity and mortality. this study investigated the frequency of postoperative aki in low risk adult patients undergoing off-pump coronary artery bypass grafting (cabg).materials & methods: all consecutive adult patients of american society of anesthe...

background: immunotherapy is the only specific treatment for scorpion envenomation. in the present study, the protective effects of polyvalent antivenom against histopathological complications in kidneys and marker changes (bun and creatinine) induced by mesobuthus eupeus (me) scorpion venom was investigated in anesthetized rabbits. methods: twenty four rabbits were randomized into four groups:...

Oxidative stress is a major contributor to kidney injury following ischemia reperfusion. Ferritin, a highly conserved iron-binding protein, is a key protein in the maintenance of cellular iron homeostasis and protection from oxidative stress. Ferritin mitigates oxidant stress by sequestering iron and preventing its participation in reactions that generate reactive oxygen species. Ferritin is co...

Current therapeutic options for acute kidney injury (AKI) are limited to the use of supportive measures and dialysis. A recent approach that has sparked great interest and gained enormous popularity is the implantation of stem cells to repair acutely damaged kidney organ. Hypoxia inducible factor-1α (HIF-1α) is effective in protecting the kidney from ischemia and nephrotoxicity. In this study, ...

background: cystatin c (cys c) has been implicated as a prognostic marker in cardiovascular disease. the aim of this study was to evaluate the value of cys c as a marker of acute kidney injury (aki) in acute heart failure (ahf), the impact of cys c and n-terminal probrain natriuretic peptides (nt-probnp) on in-hospital and 12 months mortality were also investigated. materials and methods: a tot...

BACKGROUND Acute kidney injury (AKI) is a syndrome characterized by the rapid loss of the kidney excretory function and is strongly associated with increased early and long-term patient morbidity and mortality. Early diagnosis of AKI is challenging; therefore we profiled plasma microRNA in an effort to identify potential diagnostic circulating markers of renal failure. The goal of the present s...

Aim: This study aims to investigate the possible protective effects of beta-glucan against oxidative stress caused by ischemia and reperfusion injury in kidney tissue.Methods: In study, 30 male Wistar albino rats weighing 300-350g were used (n=10). Rats randomly grouped into three groups Sham control, group (IR), + beta glucan (IR BG). had left nephrectomy, right taken for histopathologic bioch...

background: l-carnitine may prevent the incidence of aki by its antioxidant effects and improving circulation in ischemic conditions. the goal of this trial was to evaluate the impact of l-carnitine on contrast-induced nephropathy in patients undergoing elective pci. methods: totally, the patients were randomly allocated to 2 groups. the treatment group received 1 g of l-carnitine orally 3 time...

This study assessed whether endothelin-1 (ET-1) helps mediate postischemic acute kidney injury (AKI) progression to chronic kidney disease (CKD). The impact(s) of potent ETA or ETB receptor-specific antagonists (Atrasentan and BQ-788, respectively) on disease progression were assessed 24 h or 2 weeks following 30 min of unilateral ischemia in CD-1 mice. Unilateral ischemia caused progressive re...

Ischemia/reperfusion injury (I/R) is commonly related to acute kidney (AKI) and oxidative stress. Antioxidant agents are used treat this condition. Lippia sidoides a brazillian shrub with anti-inflammatory anti-oxidative properties. Thus, the aim of study evaluate effect ethanolic extract (LSEE) on in vivo vitro models AKI induced by I/R. Male Wistar rats were submitted unilateral nephrectomy i...