نتایج جستجو برای: acute kidney injury adipose tissue ischemia

تعداد نتایج: 1734170  

2016
Yong Xu Taoping Shi Axiang Xu Lei Zhang

Three-dimensional (3D) cell culture has been reported to increase the therapeutic potentials of mesenchymal stem cells (MSCs). In this study, we aimed to investigate the therapeutic effects of 3D spheroids of human adipose-derived MSCs for acute kidney injury (AKI). In vitro studies indicated that 3D spheroids of MSCs produced higher levels of extracellular matrix proteins (including collagen I...

Journal: :American journal of physiology. Renal physiology 2015
Sara Hirsch Tarek El-Achkar Lynn Robbins Jeannine Basta Monique Heitmeier Ryuichi Nishinakamura Michael Rauchman

It has been postulated that developmental pathways are reutilized during repair and regeneration after injury, but functional analysis of many genes required for kidney formation has not been performed in the adult organ. Mutations in SALL1 cause Townes-Brocks syndrome (TBS) and nonsyndromic congenital anomalies of the kidney and urinary tract, both of which lead to childhood kidney failure. Sa...

2010
Zheng Feng Joey Ting Zeni Alfonso Brian M. Strem John K. Fraser Joshua Rutenberg Hai-Chien Kuo Kai Pinkernell

BACKGROUND Acute kidney injury (AKI) represents a major clinical problem with high mortality and limited causal treatments. The use of cell therapy has been suggested as a potential modality to improve the course and outcome of AKI. METHODS We investigated the possible renoprotection of freshly isolated, uncultured adipose tissue-derived stem and regenerative cells (ADRCs) before and after cr...

2011
Jagdish Kakadiya Nehal Shah

Present study was designed to evaluate in Renoprotective activity of Pioglitazone and Glimepiride on Ischemia/reperfusion (I/R) induced renal damage in diabetic rats. Ischemia/reperfusion injury, which is commonly seen in the field of renal surgery or transplantation in diabetic condition, is a major cause of acute renal failure. Type 2 Diabetes was induced in rats by a single intraperitoneal (...

2014
Niina Koivuviita Risto Tertti Maija Heiro Ilkka Manner Kaj Metsärinne

Thromboembolic occlusion is a rare cause of acute kidney injury (AKI). It may lead to permanent loss of renal function. Our patient, who had dilated cardiomyopathy and prosthetic aortic valve, presented with AKI due to thromboembolic arterial occlusion of a solitary functioning kidney. After 2 weeks delay, local intra-arterial thrombolytic treatment with recombinant tissue plasminogen activator...

Journal: :cell journal 0

introduction: during kidney and other organ's transplantation, the organ to be transplanted, must inevitably remain out of the body with little or no blood perfusion at all, for long period of time (ischemia). this causes the release of oxygen free radicals (ofr). reperfusion (reintroduction of blood flow) will further exacerbate the initial damage caused by the ischemic insult and may result i...

Journal: :journal of research in medical sciences 0
farzaneh sharifi pour department of internal medicine, mashhad university of medical sciences, mashhad, iran maryam hami department of internal medicine, mashhad university of medical sciences, mashhad, iran massih naghibi department of internal medicine, mashhad university of medical sciences, mashhad, iran abbasali zeraati department of internal medicine, mashhad university of medical sciences, mashhad, iran sanaz arian medical doctor, kidney transplantation complications research center, mashhad university of medical sciences, mashhad, iran amir abbas azarian vice chancellor for research mashhad university of medical sciences, mashhad, iran

normal 0 false false false en-us x-none ar-sa background: acute kidney injury (aki) is commonly occurred in intensive care unit (icu) patients. the aim of the study was a comparison of rifle (risk of renal injury/injury to the kidney/failure of kidney function/loss of kidney function/end stage disease) classification with other scoring systems in the evaluation of aki in icus. materials and met...

Journal: :Medicina neotložnyh sostoânij 2021

Acute kidney injury (AKI) is a condition that develops as result of rapid decrease in the glomerular filtration rate, which leads to accumulation nitrogenous, including urea and creatinine, non-nitrogenous metabolic products with electrolytic disorders, impairment acid-base balance, volume fluid excreted by kidneys. Objective: provide review literature concerning sepsis-associated acute injury....

2017
Susanne Tewes Faikah Gueler Rongjun Chen Marcel Gutberlet Mi-Sun Jang Martin Meier Michael Mengel Dagmar Hartung Frank Wacker Song Rong Katja Hueper

PURPOSE The purpose was to characterize acute kidney injury (AKI) in C57BL/6 (B6)- and 129/Sv (Sv)-mice by noninvasive measurement of renal perfusion and tissue edema using functional MRI. METHODS Different severities of AKI were induced in B6- and Sv-mice by renal ischemia reperfusion injury (IRI). Unilateral clamping of the renal pedicle for 35 min (moderate AKI) or 45 min (severe AKI) was ...

Journal: :Revista Brasileira de terapia intensiva 2010
Kenia Machado Souza Freire Nilzete Liberato Bresolin Ana Camila Flores Farah Francisca Lígia Cirilo Carvalho José Eduardo Coutinho Góes

OBJECTIVES Acute kidney injury is characterized by sudden and generally revertible renal function impairment involving inability to maintain homeostasis. In pediatrics, the main causes of acute kidney injury are sepsis, use of nephrotoxic drugs and renal ischemia in critically ill patients. The incidence of acute kidney injury in these patients ranges from 20 to 30%, resulting in increased morb...

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