نتایج جستجو برای: acute kidney injury adipose tissue ischemia

تعداد نتایج: 1734170  

2013
Qingqing Wei Guie Dong Jian-Kang Chen Ganesan Ramesh Zheng Dong

Bax and Bak, two pro-apoptotic Bcl-2 family proteins, have been implicated in acute kidney injury following renal ischemia/reperfusion; however, definitive evidence for a role of these genes in the disease process is lacking. Here we first examined two Bax-deficient mouse models and found that only conditional Bax deletion specifically from proximal tubules could ameliorate ischemic acute kidne...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2006
Daisuke Okutani Monika Lodyga Bing Han Mingyao Liu

Acute inflammatory responses are one of the major underlying mechanisms for tissue damage of multiple diseases, such as ischemia-reperfusion injury, sepsis, and acute lung injury. By use of cellular and molecular approaches and transgenic animals, Src protein tyrosine kinase (PTK) family members have been identified to be essential for the recruitment and activation of monocytes, macrophages, n...

Journal: :iranian journal of medical sciences 0
iskender kara department of anesthesiology and reanimation, gazi university faculty of medicine, intensive care training program, anlara, turkey fatma yildirim department of pulmonology, intensive care training program, gazi university faculty of medicine, anlara, turkey esra kayacan department of internal medicine, gazi university faculty of medicine, anlara, turkey burcu bilaloğlu department of internal medicine, gazi university faculty of medicine, anlara, turkey melda turkoglu department of internal medicine, intensive care unit, gazi university faculty of medicine, anlara, turkey gülbin aygencel department of internal medicine, intensive care unit, gazi university faculty of medicine, anlara, turkey

our study evaluated the differences between early and late hemodialysis (hd) initiation in the intensive care unit (icu) according to the rifle (risk, injury, failure, loss, and end-stage renal failure) and akin (acute kidney injury network) classifications. on the assumption that early initiation of hd in critical patients according to the rifle and akin criteria decreases mortality, we retros...

Journal: :archives of trauma research 0
behrooz hashemi department of emergency medicine, shahid beheshti university of medical sciences, tehran, ir iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (shahid beheshti university of medical sciences) saeed safari department of emergency medicine, shahid beheshti university of medical sciences, tehran, ir iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (shahid beheshti university of medical sciences) mostafa hosseini department of epidemiology and biostatistics, school of public health, tehran university of medical sciences, tehran, ir iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences) mahmoud yousefifard department of physiology, school of medicine, tehran university of medical sciences, tehran, ir iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences) elham erfani department of emergency medicine, shahid beheshti university of medical sciences, tehran, ir iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (shahid beheshti university of medical sciences) alireza baratloo department of emergency medicine, shahid beheshti university of medical sciences, tehran, ir iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (shahid beheshti university of medical sciences)

conclusions a few eligible articles on seismo-nephrology were found in iran, and a limited number of current articles had poor or fair quality. as expected, the chaotic situation after mass disasters and the lack of documentation led to the loss of much important data on the diagnosis and management of victims. lessons learned from the current researches can be used as a valuable guide for futu...

2016
Yue Shang Yaw L Siow Cara K Isaak Karmin O

Ischemia-reperfusion is a common cause for acute kidney injury and can lead to distant organ dysfunction. Glutathione is a major endogenous antioxidant and its depletion directly correlates to ischemia-reperfusion injury. The liver has high capacity for producing glutathione and is a key organ in modulating local and systemic redox balance. In the present study, we investigated the mechanism by...

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000
M Ozaki S S Deshpande P Angkeow J Bellan C J Lowenstein M C Dinauer P J Goldschmidt-Clermont K Irani

Reperfusion of ischemic tissue results in the generation of reactive oxygen species that contribute to tissue injury. The sources of reactive oxygen species in reperfused tissue are not fully characterized. We hypothesized that the small GTPase Rac1 mediates the oxidative burst in reperfused tissue and thereby contributes to reperfusion injury. In an in vivo model of mouse hepatic ischemia/repe...

Journal: :American journal of physiology. Renal physiology 2010
Julio P Juncos Joseph P Grande Anthony J Croatt Robert P Hebbel Gregory M Vercellotti Zvonimir S Katusic Karl A Nath

Acute ischemic insults to the kidney are recognized complications of human sickle cell disease (SCD). The present study analyzed in a transgenic SCD murine model the early renal response to acute ischemia. Renal hemodynamics were profoundly impaired following ischemia in sickle mice compared with wild-type mice: glomerular filtration rate, along with renal plasma flow and blood flow rates, were...

2016
Patrick M. Honore H. Bryant Nguyen Michelle Gong Lakhmir S. Chawla Sean M. Bagshaw Antonio Artigas Jing Shi Olivier Joannes-Boyau Jean-Louis Vincent John A. Kellum

OBJECTIVES To examine the performance of the urinary biomarker panel tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein 7 in patients with sepsis at ICU admission. To investigate the effect of nonrenal organ dysfunction on tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein 7 in this population. METHOD In this ancillary an...

Journal: :The Journal of clinical investigation 1999
M A Daemen C van 't Veer G Denecker V H Heemskerk T G Wolfs M Clauss P Vandenabeele W A Buurman

Ischemia followed by reperfusion leads to severe organ injury and dysfunction. Inflammation is considered to be the most important cause of tissue injury in organs subjected to ischemia. The mechanism that triggers inflammation and organ injury after ischemia remains to be elucidated, although different causes have been postulated. We investigated the role of apoptosis in the induction of infla...

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