نتایج جستجو برای: acute kidney injury adipose tissue ischemia

تعداد نتایج: 1734170  

2017
Shataakshi Dube Tejasvi Matam Jessica Yen Henry E Mang Pierre C Dagher Takashi Hato Timothy A Sutton

STAT3 is a transcriptional regulator that plays an important role in coordinating inflammation and immunity. In addition, there is a growing appreciation of the role STAT3 signaling plays in response to organ injury following diverse insults. Acute kidney injury (AKI) from ischemia-reperfusion injury is a common clinical entity with devastating consequences, and the recognition that endothelial...

2017
Houshang Najafi Zeynab Mohamadi Yarijani Saeed Changizi-Ashtiyani Kamran Mansouri Masoud Modarresi Seyed Hamid Madani Bahar Bastani

Mallow (Malva sylvestris L.) has had medicinal and therapeutic uses in addition to its oral consumption. The present study was conducted to examine the protective effect of Malva sylvestris L. extract on ischemia-reperfusion-induced kidney injury and remote organ injuries in the liver. Before ischemia-reperfusion, rats in the different groups received intraperitoneal normal saline or mallow ext...

Journal: :Molecules 2016
Min Shi Liang Ma Li Zhou Ping Fu

Aristolochic acid nephropathy (AAN) is a progressive kidney disease caused by a Chinese herb containing aristolochic acid. Excessive death of renal tubular epithelial cells (RTECs) characterized the acute phase of AAN. Therapies for acute AAN were limited, such as steroids and angiotensin-receptor blockers (ARBs)/angiotensin-converting enzyme inhibitors (ACEIs). It was interesting that, in acut...

Journal: :acta medica iranica 0
shokofeh banaei department of physiology, school of medicine, ardabil university of medical sciences, ardabil, iran. nasser ahmadiasl drug applied research center, tabriz university of medical sciences, tabriz, iran. alireza alihemmati department of histology and embryology, tabriz university of medical sciences, tabriz, iran.

renal ischemia-reperfusion (ir) contributes to the development of acute renal failure (arf). oxygen free radicals are considered to be principal components involved in the pathophysiological tissue alterations observed during renal ir. the purpose of this study was to investigate the combination effect of melatonin (mel) and erythropoietin (epo), which are a potent antioxidant and anti-apoptoti...

Journal: :jundishapur journal of natural pharmaceutical products 0
khushboo k. gajjar department of pharmacology, sir takhtsinhji general hospital, government medical college, bhavnagar, india amol s. aiwale department of pharmacology, sir takhtsinhji general hospital, government medical college, bhavnagar, india ashish p. anovadiya department of pharmacology, sir takhtsinhji general hospital, government medical college, bhavnagar, india ashvin v. mevada department of pharmacology, sir takhtsinhji general hospital, government medical college, bhavnagar, india seema n. baxi department of pathology, sir takhtsinhji general hospital, government medical college, bhavnagar, india c. b. tripathi department of pharmacology, sir takhtsinhji general hospital, government medical college, bhavnagar, india; department of pharmacology, sir takhtsinhji general hospital, government medical college, bhavnagar, india. tel: +91-9825951678, fax: +91-2782422011

conclusions in our study, hydroalcoholic extract of cyperus scariosus linn. offered nephroprotection in the form of aki prevention and for the treatment of established aki. results serum creatinine was significantly increased (p < 0.05) while 24 hours urine output, urine creatinine, and serum protein were significantly decreased (p < 0.05) in rats treated with gentamicin as compared to the cont...

Journal: :Journal of immunology 2006
Jeremy S Duffield Song Hong Vishal S Vaidya Yan Lu Gabrielle Fredman Charles N Serhan Joseph V Bonventre

Omega-3 fatty acid docosahexaenoic acid is converted to potent resolvins (Rv) and protectin D1 (PD1), two newly identified families of natural mediators of resolution of inflammation. We report that, in response to bilateral ischemia/reperfusion injury, mouse kidneys produce D series resolvins (RvDs) and PD1. Administration of RvDs or PD1 to mice before the ischemia resulted in a reduction in f...

Journal: :Bratislavske lekarske listy 2015
M Sit G Aktas E E Yilmaz M Tosun E H Terzi A Alcelik

BACKGROUND Acute mesenteric ischemia (AMI) is an intestinal vascular disease with high mortality. Clinical diagnosis of acute mesenteric ischemia is difficult. Adipose tissue is an important mediator of metabolism and inflammation.Omentin is produced by visceral adipose tissue and decreased serum levels of omentin are associated with poor metabolic outcomes. We aimed to investigate whether seru...

2015
Anna J. Dare Eleanor A. Bolton Gavin J. Pettigrew J. Andrew Bradley Kourosh Saeb-Parsy Michael P. Murphy

Ischemia-reperfusion (IR) injury to the kidney occurs in a range of clinically important scenarios including hypotension, sepsis and in surgical procedures such as cardiac bypass surgery and kidney transplantation, leading to acute kidney injury (AKI). Mitochondrial oxidative damage is a significant contributor to the early phases of IR injury and may initiate a damaging inflammatory response. ...

2017
Abdulmajeed Al Drees Mahmoud Salah Khalil Mona Soliman

Acute kidney failure is the main cause of death among patients with severe trauma due to massive blood loss and hemorrhagic shock (HS). Renal cell injury is caused by tissue ischemia. Renal ischemia initiates a complex and interconnected chain of events resulting in cell injury and renal cell necrosis. Nitric oxide plays a crucial role in renal function and can be inhibited by aminoguanidine (A...

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